NDLI: Rutin- and selenium-attenuated cadmium-induced testicular pathophysiology in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Abarikwu, S. O. Iserhienrhien, B. O. Badejo, T. A.
Description	Country affiliation: Nigeria Author Affiliation: Abarikwu SO ( Department of Chemical Sciences, College of Natural Sciences, Redeemer's University, Redemption City, Ogun State, Nigeria. abarikwus@run.edu.ng)
Abstract	Cadmium (Cd) is known to cause oxidative damage in the testes of rats. The aim of this study was to investigate the protective role of rutin (RUT, 30 mg/kg) and selenium (Se, 0.15 ppm) alone or in combination against Cd (200 ppm)-induced lipid peroxidation, steroidogenesis and changes in antioxidant defence system in the rat testes. The obtained results showed that Cd increased lipid peroxidation and abnormal sperm count and decreased plasma testosterone, lactate dehydrogenase, acid phosphatase, alkaline phosphatase and testicular steroidogenic enzymes: 3ß-hydroxysteroid dehydrogenase (HSD), 17ß-HSD activities as well as epididymal sperm counts and motility, while RUT and Se treatment reversed this change to control values. Acute intoxication with Cd was also followed by significantly decreased activity of the antioxidant defence system (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione (GSH), and glutathione-S-transferase (GST)). Treatment with RUT and Se reversed Cd-induced alterations of antioxidant defence system and significantly prevented Cd-induced testes damage and depletion of plasma and testicular Se levels. RUT and Se appear not to have more profound effects than their separate effects against Cd-induced testicular toxicity, although Se was more potent than RUT in the recovery of testosterone levels. These results suggest that both RUT and Se do not have synergistic role against Cd-induced testicular injury.
File Format	HTM / HTML
ISSN	09603271
Issue Number	4
Volume Number	32
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2013-04-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Antioxidants Administration & Dosage Cadmium Toxicity Environmental Pollutants Rutin Selenium Testis Drug Effects Animals Blood Pharmacokinetics Catalase Metabolism Glutathione Glutathione Peroxidase Glutathione Reductase Male Rats Rats, Wistar Sperm Count Sperm Motility Superoxide Dismutase Pathology Physiopathology Testosterone Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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