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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shim, Ilseob Kim, Hyun-Mi Yang, Sangyoung Choi, Min Seo, Gyun-Baek Lee, Byung-Woo Yoon, Byung-Il Kim, Pilje Choi, Kyunghee |
| Description | Author Affiliation: Shim I ( Department of Environmental Health Research, National Institute of Environmental Research, Incheon, Republic of Korea.); Kim HM ( Department of Environmental Health Research, National Institute of Environmental Research, Incheon, Republic of Korea.); Yang S ( Department of Environmental Health Research, National Institute of Environmental Research, Incheon, Republic of Korea.); Choi M ( Department of Environmental Health Research, National Institute of Environmental Research, Incheon, Republic of Korea.); Seo GB ( Department of Environmental Health Research, National Institute of Environmental Research, Incheon, Republic of Korea.); Lee BW ( College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea.); Yoon BI ( College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea similseob@korea.kr byoon@kangwon.ac.kr.); Kim P ( Department of Environmental Health Research, National Institute of Environmental Research, Incheon, Republic of Korea.); Choi K ( Department of Environmental Health Research, National Institute of Environmental Research, Incheon, Republic of Korea.) |
| Abstract | Talc is a mineral that is widely used in cosmetic products, antiseptics, paints, and rubber manufacturing. Although the toxicological effects of talc have been studied extensively, until now no detailed inhalation study of talc focusing on oxidative stress has been done. This repeated 4 weeks whole-body inhalation toxicity study of talc involved Sprague-Dawley rats. Male and female groups of rats were exposed to inhaled talc at 0, 5, 50, and 100 mg/m(3) for 6 hours daily, 5 days/week for 4 weeks. The objective was to identify the 4-week inhalation toxicity of talc and investigate antioxidant activity after exposure to talc. There were no treatment-related symptoms or mortality in rats treated with talc. Glucose (GLU) was decreased significantly in male rats exposed to 50 and 100 mg/m(3) of talc. Histopathological examination revealed infiltration of macrophages on the alveolar walls and spaces near the terminal and respiratory bronchioles. In male and female rats exposed to 100 mg/m(3) talc, expression of superoxide dismutase 2, a typical biological indicator of oxidative damage, was significantly increased. Thus, inhalation of talc induces macrophage aggregations and oxidative damage in the lung. |
| File Format | HTM / HTML |
| ISSN | 10915818 |
| Issue Number | 6 |
| Volume Number | 34 |
| e-ISSN | 1092874X |
| Journal | International Journal of Toxicology |
| Language | English |
| Publisher | Sage Publication |
| Publisher Date | 2015-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Macrophages Drug Effects Superoxide Dismutase Biosynthesis Talc Toxicity Administration, Inhalation Animals Antioxidants Metabolism Blood Glucose Bronchioles Pathology Female Glutathione Peroxidase Lung Male Oxidative Stress Pulmonary Alveoli Rats Rats, Inbred F344 Rats, Sprague-dawley Genetics Administration & Dosage Up-regulation Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology |
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