NDLI: Spontaneous nonneoplastic lesions in control Syrian hamsters in three 24-month long-term carcinogenicity studies.

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Spontaneous nonneoplastic lesions in control Syrian hamsters in three 24-month long-term carcinogenicity studies.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	McInnes, Elizabeth F. Ernst, Heinrich Germann, Paul-Georg
Description	Country affiliation: Australia Author Affiliation: McInnes EF ( Cerberus, Thebarton, South Australia, Australia efmcinnes@aol.com.); Ernst H ( Fraunhofer Institute for Toxicology, and Experimental Medicine (ITEM), Hannover, Germany.); Germann PG ( Nycomed GmbH, Konstanz, Germany.)
Abstract	Information about the incidence of spontaneously occurring, nonneoplastic background findings in Syrian hamsters is essential if Syrian hamsters are to be used for toxicity studies. Male and female Syrian hamsters of the strain Han:AURA from the Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) breeding colony were maintained as control animals for carcinogenicity studies and were examined for the presence of nonneoplastic background findings either when they died or when the study was terminated. The nonneoplastic background lesions observed at an incidence of >50% (high), >25% (moderate), and >10% (low) in either male or female animals or in both sexes in one or more long-term studies are detailed. The results are compared to previous published reports of nonneoplastic, spontaneous background lesions in Syrian hamsters. Background information about the incidence of background lesions in Syrian hamsters on short- and long-term studies is useful to both toxicologists and toxicological pathologists.
File Format	HTM / HTML
ISSN	01926233
Issue Number	2
Volume Number	43
e-ISSN	15331601
Journal	Toxicologic Pathology
Language	English
Publisher	Sage Publications
Publisher Date	2015-02-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Discipline Pathology Animal Diseases Epidemiology Pathology Carcinogenicity Tests Mesocricetus Physiology Standards Toxicology Mortality Animals Cricetinae Female Incidence Male Neoplasms Reference Standards Journal Article
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Toxicology Pathology and Forensic Medicine

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