NDLI: Increased expression of claudin-1 and claudin-7 in liver cirrhosis and hepatocellular carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Holczbauer, Ágnes Gyöngyösi, Benedek Lotz, Gábor Törzsök, Péter Kaposi-Novák, Pál Szijártó, Attila Tátrai, Péter Kupcsulik, Péter Schaff, Zsuzsa Kiss, András
Description	Author Affiliation: Holczbauer Á ( 2nd Department of Pathology, Semmelweis University Budapest, Ülloi út 93., 1091, Budapest, Hungary, holczagnes@yahoo.com.)
Abstract	Claudins have been reported to be differentially regulated in malignancies and implicated in the process of carcinogenesis and tumor progression. Claudin-1 has been described as key factor in the entry of hepatitis C virus (HCV) into hepatocytes and as promoter of epithelial-mesenchymal transition in liver cells. The objective of the current study was to characterize claudin expression in hepatocellular carcinoma (HCC) as well as HCC-surrounding and normal liver samples with respect to cirrhosis and HCV infection. Expression of claudin-1, -2, -3, -4, and -7 was measured by morphometric analysis of immunohistochemistry, and Western blotting in 30 HCCs with 30 corresponding non-tumorous tissues and 6 normal livers. Claudin-1 and -7 protein expression was found significantly elevated in cirrhosis when compared with non-cirrhotic liver. HCCs developed in cirrhotic livers showed even higher expression of claudin-1 contrary to decreased claudin-7 expression when compared with cirrhosis. With reference to HCV status, HCCs or surrounding livers of HCV-infected samples did not show significant alterations in claudin expression when compared with HCV-negative specimens. Cirrhotic transformation associates with elevated claudin-1 and -7 expressions in both non-tumorous liver and HCC. The fact that no significant differences in claudin expression were found regarding HCV-positivity in our sample set suggests that HCV infection alone does not induce a major increase in the total amount of its entry co-factor claudin-1. Increased expression of claudin-1 seems to be a consequence of cirrhotic transformation and might contribute to a more effective HCV entry and malignant transformation.
File Format	HTM / HTML
ISSN	12194956
Issue Number	3
Volume Number	20
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2014-07-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Biological Markers Metabolism Carcinoma, Hepatocellular Claudins Liver Cirrhosis Liver Neoplasms Liver Blotting, Western Pathology Case-control Studies Female Humans Immunoenzyme Techniques Male Middle Aged Neoplasm Staging Prognosis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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