NDLI: Associations between SNPs within antioxidant genes and the risk of prostate cancer in the Siberian region of Russia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Oskina, N. A. Ð rmolenko, N. A. Boyarskih, U. A. Lazarev, A. F. Petrova, V. D. Ganov, D. I. Tonacheva, O. G. Lifschitz, G. I. Filipenko, M. L.
Spatial Coverage	Russia
Description	Author Affiliation: Oskina NA ( Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia, nattasha.o@gmail.com.)
Abstract	In the present study we investigated the association of a number of polymorphic changes in antioxidant system genes (SNPs rs1050450 in the GPX1 gene, rs1695 and rs1138272 in the GSTP1 gene and rs4880 in the MnSOD gene) with the risk of prostate cancer. The association of disease stage and PSA levels with specific genotypes was also analyzed. A study was conducted with the participation of 736 Russian men. We compared the frequency of occurrence of the studied alleles in patients with prostate cancer (392) to a control group (344) of men without a history of cancer. Genotyping was performed by real-time PCR. Comparison of frequencies of alleles and genotypes were performed using logistic regression analysis. No statistically significant association with the risk of prostate cancer was found for any of the SNPs studied (p > 0.05). For SNP rs1695 in the GSTP1 gene, a correlation with cancer disease stage was observed: a GG genotype is significantly more common in patients with PCa in the 3rd and 4th stage than 1st and 2nd (OR[95%CI] = 2.66[1.15-6.18], p = 0.02). Both studied SNPs of GSTP1 gene are associated with the level of PSA: the GG rs1695 and the TT rs1138272 genotypes are associated with higher PSA levels (p = 1.5*10(-3)).
File Format	HTM / HTML
ISSN	12194956
Issue Number	3
Volume Number	20
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2014-07-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Antioxidants Metabolism Glutathione Peroxidase Genetics Glutathione S-transferase Pi Polymorphism, Single Nucleotide Prostatic Neoplasms Superoxide Dismutase Adult Aged Case-control Studies Follow-up Studies Genetic Predisposition To Disease Genotype Humans Male Middle Aged Neoplasm Staging Prognosis Pathology Risk Factors Russia Survival Rate Journal Article
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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