NDLI: Characterization of the attenuation of breast cancer bone metastasis in mice by zoledronic acid using (99m)Tc bone scintigraphy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, Chunyu Yang, Shunfang Sun, Zhenping Han, Xianghui Ye, Yiyi Liu, Sheng
Description	Country affiliation: China Author Affiliation: Wu C ( Department of Breast Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.)
Abstract	Metastatic breast cancer often metastasizes to bone. The purposes of the study were (1) to evaluate the use of (99m)Tc-MDP bone scintigraphy for detection of metastatic bone lesions, and (2) to determine the efficacy of zoledronic acid in mice with breast cancer bone metastasis. All tumor-bearing mice were analyzed with radionuclide bone scintigraphy, X-ray, and histological analysis. The metastatic bone tissue was also harvested and analyzed by western blotting and real-time qPCR. Interestingly, zoledronic acid significantly decreased both the tumor burden and the incidence of bone metastasis in mice. In addition, histomorphometric, stereological, and molecular biology analyses demonstrated that zoledronic acid may function to inhibit breast cancer cell growth in the bone microenvironment and regulate the function of osteoblasts and osteoclasts in tumor-bearing mice. Finally, the attenuation of breast cancer bone metastasis using zoledronic acid can be accurately characterized by (99m)Tc bone scintigraphy in mice.
File Format	HTM / HTML
ISSN	12194956
Issue Number	3
Volume Number	20
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2014-07-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Bone Density Conservation Agents Therapeutic Use Bone Neoplasms Prevention & Control Breast Neoplasms Diphosphonates Imidazoles Technetium Tc 99m Medronate Animals Tumor Markers, Biological Genetics Metabolism Blotting, Western Secondary Pathology Female Humans Mice Mice, Inbred Balb C Mice, Nude Rna, Messenger Radionuclide Imaging Radiopharmaceuticals Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Tumor Cells, Cultured Xenograft Model Antitumor Assays Journal Article
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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