NDLI: Association of genetic polymorphisms in HSD17B1, HSD17B2 and SHBG genes with hepatocellular carcinoma risk.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Lu Shun Yuan, Fang Guan, Xuan Li, Juan Liu, Xin Lian Sun, Jing Liu, Bo Ma, Wei Deng, Feng Mei
Description	Author Affiliation: Zhang LS ( Department of Pathology and Pathophysiology, Cheng Du Medical College, Chengdu, 610500, China, zhangls2012@163.com.)
Abstract	Genetic polymorphisms of enzymes involved in estrogen synthesizing/transporting can influence the risk of hormone-dependent diseases. The incidence rate and relative risk for hepatocellular carcinoma (HCC) are higher in men than in women. This study was conducted to explore the relationship of single nucleotide polymorphisms (SNPs) in 17 ß-Hydroxysteroid dehydrogenases (HSD17B1 and HSD17B2) and sex hormone-binding globulin (SHBG) genes with the risk of HCC within Chinese Han population. Polymorphisms of HSD17B1 rs676387, HSD17B2 rs8191246 and SHBG rs6259 were genotyped in 253 HCC patients and 438 healthy control subjects using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Significantly increased HCC risk was found to be associated with T allele of rs676387 and G allele of rs8191246. Increased HCC risks were found in different genetic model (TT genotype in a recessive model, T allele carriers in a dominant model, TT genotype and TG genotype in a codominant model for HSD17B1 rs676387, G allele carriers in a dominant model and AG genotype in a codominant model for HSD17B2 rs8191246, respectively). No association between SHBG rs6259 and HCC risk was observed. The present study provided evidence that HSD17B1 rs676387 and HSD17B2 rs8191246 were association with HCC development. Further studies in diverse ethnic population with larger sample size were recommended to confirm the findings.
File Format	HTM / HTML
ISSN	12194956
Issue Number	3
Volume Number	20
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2014-07-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Carcinoma, Hepatocellular Genetics Estradiol Dehydrogenases Liver Neoplasms Polymorphism, Single Nucleotide Receptors, Cell Surface Case-control Studies Cohort Studies Female Follow-up Studies Genetic Predisposition To Disease Genotype Humans Male Middle Aged Neoplasm Staging Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Prognosis Risk Factors Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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