NDLI: In vitro and in vivo evaluation of the chitosan/Tur composite film for wound healing applications.

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In vitro and in vivo evaluation of the chitosan/Tur composite film for wound healing applications.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zou, Qin Cai, Bin Li, Junfeng Li, Jidong Li, Yubao
Description	Country affiliation: China Author Affiliation: Zou Q ( a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.); Cai B ( a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.); Li J ( b Department of Materials Science & Engineering , Chengdu University of Technology , Chengdu , China.); Li J ( a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.); Li Y ( a Research Center for Nano-Biomaterials, Analytical & Testing Center , Sichuan University , Chengdu , China.)
Abstract	We have developed tourmaline/chitosan (Tur/CS) composite films for wound healing applications. The characteristics of composite films were studied by optical microscope, infrared spectra and X-ray diffraction. Tur particles were uniformly distributed in the CS film and the crystal structure of CS was not remarkably changed except the decrease of crystallinity. The influence of Tur on wound healing applications was characterized by modulating Tur concentrations in the Tur/CS composite film prepared by loading Tur powder into CS matrix with different proportion (0, 1/40 and 1/10). Then L929 cells were co-cultured on the composite films to access the cytotoxicity in vitro. Tur concentrations strongly influenced cell process extension. Tur/CS composite film with 1/40 mass ratio could promote the cell adhesion and proliferation. Fewer and shorter processes were observed at high Tur density. When the composite films were transplanted on porcine full-thickness burn wounds, histological results demonstrated that the Tur/CS group with 1/40 mass ratio had a significantly higher number of newly-formed and mature blood vessels, and fastest regeneration of dermis. Based on the observed facts these films can be tailored for their potential utilization in wound healing and skin tissue engineering applications.
File Format	HTM / HTML
ISSN	09205063
Journal	Journal of Biomaterials Science, Polymer Edition
e-ISSN	15685624
Language	English
Publisher	Taylor & Francis
Publisher Date	2017-02-13
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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