NDLI: Cationic copolymer augments membrane permeabilizing activity of an amphiphilic peptide.

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Cationic copolymer augments membrane permeabilizing activity of an amphiphilic peptide.

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Cationic copolymer augments membrane permeabilizing activity of an amphiphilic peptide.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sakamoto, Wakako Ochiai, Takuro Shimada, Naohiko Maruyama, Atsushi
Description	Country affiliation: Japan Author Affiliation: Sakamoto W ( a Department of Life Science and Technology , Tokyo Institute of Technology , Yokohama , Japan.); Ochiai T ( a Department of Life Science and Technology , Tokyo Institute of Technology , Yokohama , Japan.); Shimada N ( a Department of Life Science and Technology , Tokyo Institute of Technology , Yokohama , Japan.); Maruyama A ( a Department of Life Science and Technology , Tokyo Institute of Technology , Yokohama , Japan.)
Abstract	Membrane disruptive peptides (also called membrane fusogenic peptides) have been employed for cytosolic delivery of macromolecules such as nucleic acids and proteins. We reported previously that the cationic graft copolymer, poly(allylamine)-graft-dextran (PAA-g-Dex), augments membrane disruptive activity of the negatively charged E5 peptide. Strong membrane disruptive activity was observed in the presence of the copolymer at both acidic and neutral pH. In this paper, activities of E5/PAA-g-Dex mixture were further explored. Membrane permeabilization activity of E5/PAA-g-Dex was dependent on concentrations of both E5 and PAA-g-Dex, indicating that a complex between E5 and PAA-g-Dex produced the activity. Since the activity of peptide/PAA-g-Dex was peptide sequence-specific, we reasoned that PAA-g-Dex activated membrane-permeabilization activity by facilitating folding of E5 into its active conformation. The membrane permeabilization activity of E5/PAA-g-Dex resulted in transportation of bovine serum albumin into HL-60 cells with less cellular toxicity than digitonin, a naturally occurring surfactant used for delivery of macromolecules into cells.
File Format	HTM / HTML
ISSN	09205063
Journal	Journal of Biomaterials Science, Polymer Edition
e-ISSN	15685624
Language	English
Publisher	Taylor & Francis
Publisher Date	2017-02-17
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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