NDLI: Injectable Conductive Collagen/Alginate/Polypyrrole Hydrogels as a Biocompatible System for Biomedical Applications.

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Injectable Conductive Collagen/Alginate/Polypyrrole Hydrogels as a Biocompatible System for Biomedical Applications.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ketabat, Farinaz Karkhaneh, Akbar Mehdinavaz Aghdam, Rouhollah Ahmadi Tafti, Seyed Hossein
Description	Country affiliation: Iran Author Affiliation: Ketabat F ( a Department of Biomedical Engineering, Amirkabir University of Technology Amirkabir University of Technology Tehran , Iran.); Karkhaneh A ( b Biomedical Engineering Faculty , Islamic Azad University, Science and Research Branch , Tehran , Iran.); Mehdinavaz Aghdam R ( b Biomedical Engineering Faculty , Islamic Azad University, Science and Research Branch , Tehran , Iran.); Ahmadi Tafti SH ( c Tehran Heart Hospital Research Center, Tehran University of Medical Sciences , Tehran , Iran.)
Abstract	Recently, Injectable Conducting Hydrogel (ICH) systems have gained much attention for tissue engineering and regenerative medicine. These systems can promote the regeneration of tissues responding to electrical responses. In this study, a novel ICH system was introduced. To achieve this system, firstly, a soluble non-toxic polypyrrole (PPy) synthesized by grafting pyrrole on alginate (Alg) backbone (Alg-graft-PPy), and then, ICH systems were prepared by the given ratios of Alg-graft-PPy, Alg, and collagen (Col). Three different amounts of Col (0.5, 1, and 1.5 mg/ml) were added to the system including Alg-graft-PPy: Alg wt. % with the ratio of 20:80 and 30:70. FTIR spectroscopy, electrical conductivity, viscosity, syringeability, gelation time, and MTT assay were performed in order to characterize the produced hydrogels. Due to the rheological behavior of 20:80 (Alg-graft-PPy: Alg wt. %), it was recognized more suitable to inject. Also this system associated with 0.5 mg/ml Col introduced as the best sample with respect to its viscosity and injectability. This ICH system has shown high conductivity in addition to a good level of cell viability and syringeability. With respect to properties of the produced ICH system, it can be applied for bone, nerve, muscle and cardiac cells, which respond to electrical impulses.
File Format	HTM / HTML
ISSN	09205063
Journal	Journal of Biomaterials Science, Polymer Edition
e-ISSN	15685624
Language	English
Publisher	Taylor & Francis
Publisher Date	2017-03-02
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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