NDLI: Fabrication and characterization of chitosan/OGP coated porous poly(Îµ-caprolactone) scaffold for bone tissue engineering.

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Fabrication and characterization of chitosan/OGP coated porous poly(Îµ-caprolactone) scaffold for bone tissue engineering.

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Fabrication and characterization of chitosan/OGP coated porous poly(Îµ-caprolactone) scaffold for bone tissue engineering.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cui, Zhixiang Lin, Luyin Si, Junhui Luo, Yufei Wang, Qianting Lin, Yongnan Wang, Xiaofeng Chen, Wenzhe
Description	Country affiliation: China Author Affiliation: Cui Z ( a School of Materials Science and Engineering, Fujian University of Technology , Fuzhou , China.); Lin L ( b Fujian Provincial Key Laboratory of Advanced Materials Processing and Application , Fuzhou , China.); Si J ( c School of Materials Science and Engineering, Fuzhou University , Fuzhou , China.); Luo Y ( d National Center for International Research of Micro-nano Molding Technology & Key Laboratory for Micro Molding Technology of Henan Province , Zhengzhou University , Zhengzhou , China.); Wang Q ( a School of Materials Science and Engineering, Fujian University of Technology , Fuzhou , China.); Lin Y ( b Fujian Provincial Key Laboratory of Advanced Materials Processing and Application , Fuzhou , China.); Wang X ( a School of Materials Science and Engineering, Fujian University of Technology , Fuzhou , China.); Chen W ( b Fujian Provincial Key Laboratory of Advanced Materials Processing and Application , Fuzhou , China.)
Abstract	As one of the stimulators on bone formation, osteogenic growth peptide (OGP) improves both proliferation and differentiation of the bone cells in vitro and in vivo. The aim of this work was the preparation of three dimensional porous poly(Îµ-caprolactone) (PCL) scaffold with high porosity, well interpore connectivity, and then its surface was modified by using chitosan (CS)/OGP coating for application in bone regeneration. In present study, the properties of porous PCL and CS/OGP coated PCL scaffold, including the microstructure, water absorption, porosity, hydrophilicity, mechanical properties, and biocompatibility in vitro were investigated. Results showed that the PCL and CS/OGP-PCL scaffold with an interconnected network structure have a porosity of more than 91.5, 80.8%, respectively. The CS/OGP-PCL scaffold exhibited better hydrophilicity and mechanical properties than that of uncoated PCL scaffold. Moreover, the results of cell culture test showed that CS/OGP coating could stimulate the proliferation and growth of osteoblast cells on CS/OGP-PCL scaffold. These finding suggested that the surface modification could be a effective method on enhancing cell adhesion to synthetic polymer-based scaffolds in tissue engineering application and the developed porous CS/OGP-PCL scaffold should be considered as alternative biomaterials for bone regeneration.
File Format	HTM / HTML
ISSN	09205063
Journal	Journal of Biomaterials Science, Polymer Edition
e-ISSN	15685624
Language	English
Publisher	Taylor & Francis
Publisher Date	2017-03-14
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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