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Effects of lead and/or cadmium on the distribution patterns of some essential trace elements in immature female rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Lin Zhou, Xuelei Yang, Dubao Wang, Zhenyong
Description	Country affiliation: China Author Affiliation: Wang L ( College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian, China.)
Abstract	Lead acetate (300 mg/L) and/or cadmium chloride (50 mg/L) were administered as drinking water to Sprague-Dawley rats for 9 weeks to investigate the effects of concurrent exposure to lead and cadmium on the distribution patterns of five essential trace elements. Inductively coupled plasma mass spectrometry was used to determine the concentrations of zinc, copper, manganese, selenium and iron in the urine at different exposure times, as well as their levels in the renal cortex and serum at the end of treatment. Compared with the control group, exposure to lead and/or cadmium resulted in a significant increase in the urinary excretion of these five elements during the experiment, whereas significant decreased levels of these elements were found in kidney and serum. In conclusion, increased urinary loss of antioxidant trace elements due to lead and/or cadmium exposure induced the deficiency of antioxidants in the body, which could result in further oxidative damage. Moreover, there was an obvious synergistic effect of lead combined with cadmium on the distribution patterns of these essential trace elements, which may be related to the severity of co-exposure to these two metals.
File Format	HTM / HTML
ISSN	09603271
Issue Number	12
Volume Number	30
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2011-12-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Cadmium Chloride Pharmacokinetics Environmental Pollutants Pharmacology Organometallic Compounds Trace Elements Animals Antioxidants Toxicity Drinking Water Drug Synergism Female Kidney Cortex Chemistry Drug Effects Metabolism Rats Rats, Sprague-dawley Spectrophotometry, Atomic Analysis Urine Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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