NDLI: Thymoquinone ameliorates lead-induced brain damage in Sprague Dawley rats.

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Thymoquinone ameliorates lead-induced brain damage in Sprague Dawley rats.

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Thymoquinone ameliorates lead-induced brain damage in Sprague Dawley rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Radad, Khaled Hassanein, Khaled Al-Shraim, Mubarak Moldzio, Rudolf Rausch, Wolf-Dieter
Description	Author Affiliation: Radad K ( Department of Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, Egypt. Electronic address: khaledradad@hotmail.com.)
Abstract	The present study aims to investigate the protective effects of thymoquinone, the major active ingredient of Nigella sativa seeds, against lead-induced brain damage in Sprague-Dawley rats. In which, 40 rats were divided into four groups (10 rats each). The first group served as control. The second, third and fourth groups received lead acetate, lead acetate and thymoquinone, and thymoquinone only, respectively, for one month. Lead acetate was given in drinking water at a concentration of 0.5 g/l (500 ppm). Thymoquinone was given daily at a dose of 20mg/kg b.w. in corn oil by gastric tube. Control and thymoquinone-treated rats showed normal brain histology. Treatment of rats with lead acetate was shown to produce degeneration of endothelial lining of brain blood vessels with peri-vascular cuffing of mononuclear cells consistent to lymphocytes, congestion of choroid plexus blood vessels, ischemic brain infarction, chromatolysis and neuronal degeneration, microglial reaction and neuronophagia, degeneration of hippocampal and cerebellar neurons, and axonal demyelination. On the other hand, co-administration of thymoquinone with lead acetate markedly decreased the incidence of lead acetate-induced pathological lesions. Thus the current study shed some light on the beneficial effects of thymoquinone against neurotoxic effects of lead in rats.
File Format	HTM / HTML
ISSN	09402993
Issue Number	1
Volume Number	66
e-ISSN	16181433
Journal	Experimental and Toxicologic Pathology
Language	English
Publisher	Elsevier
Publisher Date	2014-01-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Discipline Pathology Benzoquinones Pharmacology Brain Drug Effects Neuroprotective Agents Organometallic Compounds Toxicity Animals Pathology Male Rats Rats, Sprague-dawley Journal Article
Content Type	Text
Resource Type	Article
Subject	Cell Biology Toxicology Pathology and Forensic Medicine

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