NDLI: Effects of low-level arsenic exposure on urinary N-acetyl-ß-D-glucosaminidase activity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Eom, S-Y Lee, Y-C Yim, D-H Lee, C-H Kim, Y-D Choi, B-S Park, C-H Yu, S-D Kim, D-S Park, J-D Kim, H.
Spatial Coverage	Republic of Korea
Description	Author Affiliation: Eom SY ( Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.)
Abstract	This study was aimed to evaluate whether renal tubular function is impaired by exposure to relatively low concentrations of arsenic. Mean urinary arsenic concentrations and N-acetyl-ß-D-glucosaminidase (NAG) activities were compared among 365 and 502 Korean men and women, respectively, in relation to gender, smoking, alcohol consumption, and recent seafood consumption. The study subjects were divided into 4 groups according to urinary NAG activity and seafood consumption prior to urine sampling, and the correlation between arsenic concentration and urinary NAG activity was tested for each group. The mean urinary arsenic level was higher in women, non-smokers, and non-drinkers in comparison to men, smokers, and drinkers, respectively. Individuals who consumed seafood within 3 days prior to urine sampling showed a higher mean urinary arsenic level than those who did not. The correlation between urinary arsenic concentration and NAG activity in urine was significant only in subjects who did not consume seafood within 3 days prior to urine sampling and whose urinary NAG activity was 7.44 U/g creatinine (75th percentile) or higher. The urinary arsenic concentration was a significant determinant of urinary NAG activity in subjects with NAG activity higher than 7.44 U/g creatinine and especially in those who had not consumed seafood recently. These facts suggest that a relatively low-level exposure to inorganic arsenic produces renal tubular damage in humans.
File Format	HTM / HTML
ISSN	09603271
Issue Number	12
Volume Number	30
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2011-12-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Acetylglucosaminidase Urine Arsenic Poisoning Enzymology Arsenicals Adverse Effects Environmental Exposure Environmental Monitoring Kidney Drug Effects Adult Aged Dose-response Relationship, Drug Feeding Behavior Female Food Contamination Humans Metabolism Male Middle Aged Republic Of Korea Seafood Analysis Water Supply Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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