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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yu, Chengjun Tai, Fadao Song, Zhenzhen Wu, Ruiyong Zhang, Xia He, Fengqin |
| Description | Country affiliation: China Author Affiliation: Yu C ( Institute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.) |
| Abstract | Bisphenol A (BPA) is a widespread endocrine disrupting chemical that influences adult physiology and behavior after perinatal exposure. However, it is not clear if pubertal exposure to BPA exerts hormone dependent effects on behaviors. Using C57BL/6J mice, we sought to determine how pubertal exposure to BPA affects locomotion, exploration, anxiety and sociability in adulthood. Compared to controls, pubertal exposure to BPA or E(2) (17ß-estradiol) significantly altered female exploratory and anxiety behavior. Moreover, BPA and E(2)-treated female mice displayed increased levels of affiliation to female stimulus mice and decreased levels of affiliation to male stimulus mice; while our control males showed affiliation preference to female stimulus. These results indicate that pubertal exposure to BPA or E(2) may masculinize female social and emotional behavior. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 31 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Behavior, Animal Drug Effects Endocrine Disruptors Toxicity Phenols Animals Anxiety Psychology Benzhydryl Compounds Estradiol Pharmacology Exploratory Behavior Female Interpersonal Relations Male Mice Mice, Inbred C57bl Motor Activity Sex Characteristics Sexual Behavior, Animal Social Behavior Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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