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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gramec Skledar, Darja Peterlin Masic, Lucija |
| Description | Country affiliation: Slovenia Author Affiliation: Gramec Skledar D ( Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.); Peterlin Masic L ( Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. Electronic address: lucija.peterlin@ffa.uni-lj.si.) |
| Abstract | Structural analogs of bisphenol A are commonly used as its alternatives in industrial and commercial applications. Nevertheless, the question arises whether the use of other bisphenols is justified as replacements for bisphenol A in mass production of plastic materials. To evaluate the influence of metabolic reactions on endocrine activities of bisphenols, we conducted a systematic review of the literature. Knowledge about the metabolic pathways and enzymes involved in metabolic biotransformations is essential for understanding and predicting mechanisms of toxicity. Bisphenols are metabolized predominantly by the glucuronidation reaction, which is considered their most important detoxification pathway, as based on current knowledge, glucuronides do not have activity on endocrine receptors. In contrast, several oxidative metabolites of bisphenols with enhanced endocrine activities are presented, and these findings indicate that oxidative metabolites of bisphenols can still have endocrine activities in humans. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Volume Number | 47 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-10-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Benzhydryl Compounds Metabolism Toxicity Endocrine Disruptors Phenols Animals Chemistry Humans Polybrominated Biphenyls Sulfones Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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