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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Weber, Daniel N. Hoffmann, Raymond G. Hoke, Elizabeth S. Tanguay, Robert L. |
| Description | Country affiliation: United States Author Affiliation: Weber DN ( a Children's Environmental Health Sciences Core Center , University of Wisconsin-Milwaukee , Milwaukee , Wisconsin , USA.) |
| Abstract | Developmental bisphenol A (BPA) exposure is associated with adverse behavioral effects, although underlying modes of action remain unclear. Because BPA is a suspected xenoestrogen, the objective was to identify sex-based changes in adult zebrafish social behavior developmentally exposed to BPA (0.0, 0.1, or 1 µM) or one of two control compounds (0.1 µM 17ß-estradiol [E2], and 0.1 µM GSK4716, a synthetic estrogen-related receptor γ ligand). A test chamber was divided lengthwise so each arena held one fish unable to detect the presence of the other fish. A mirror was inserted at one end of each arena; baseline activity levels were determined without mirror. Arenas were divided into three computer-generated zones to represent different distances from mirror image. Circadian rhythm patterns were evaluated at 1-3 (= AM) and 5-8 (= PM) h postprandial. Adult zebrafish were placed into arenas and monitored by digital camera for 5 min. Total distance traveled, percent of time spent at mirror image, and number of attacks on mirror image were quantified. E2, GSK4716, and all BPA treatments dampened male activity and altered male circadian activity patterns; there was no marked effect on female activity. BPA induced nonmonotonic effects (response curve changes direction within range of concentrations examined) on male percent of time at mirror only in AM. All treatments produced increased percent of time at the mirror during PM. Male attacks on the mirror were reduced by BPA exposure only during AM. There were sex-specific effects of developmental BPA on social interactions, and time of day of observation affected results. |
| File Format | HTM / HTML |
| ISSN | 15287394 |
| e-ISSN | 10872620 |
| DOI | 10.1080/15287394.2015.958419 |
| Journal | Journal of Toxicology and Environmental Health, Part A |
| Issue Number | 1 |
| Volume Number | 78 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Environmental Health Discipline Toxicology Behavior, Animal Drug Effects Benzhydryl Compounds Toxicity Phenols Social Behavior Animals Dose-response Relationship, Drug Endocrine Disruptors Estradiol Metabolism Sex Factors Toxicity Tests Zebrafish Growth & Development Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Toxicology |
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