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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Haldar, Pallab Kanti Bhattacharya, Sanjib Dewanjee, Saikat Mazumder, Upal Kanti |
| Description | Author Affiliation: Haldar PK ( Department of Pharmaceutical Technology, Jadavpur University, Raja SC Mallick Rd, Kolkata 700032, West Bengal, India. pallab haldar@rediffmail.com) |
| Abstract | Present study reports the chemopreventive effect of methanol extract of Wedelia calendulaceae (MEWC) against 20-methylcholanthrene (20-MC) induced carcinogenesis in Swiss albino mice. MEWC was administered orally at 250 and 500 mg/kg body weight for 90 consecutive days after 24h of single subcutaneous administration of 20-MC (200 µg) in mice and observed for 15 weeks to record tumor incidence (fibrosarcoma) and survival. After 15 weeks the mice were sacrificed for the estimation of hematological profiles and liver biochemical parameters viz. lipid peroxidation, reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT). MEWC treatment markedly reduced tumor incidence and prolonged life span of sarcoma bearing mice as compared to 20-MC control. Hematological profiles were significantly (p<0.001) restored to normal levels in MEWC treated mice. MEWC treatment significantly (p<0.001) modulated the aforesaid liver biochemical parameters as compared to 20-MC control. Therefore, W. calendulaceae possess remarkable chemopreventive efficacy in Swiss mice. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 31 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Anticarcinogenic Agents Pharmacology Carcinogens Antagonists & Inhibitors Toxicity Methylcholanthrene Wedelia Chemistry Animals Blood Cell Count Blood Chemical Analysis Catalase Metabolism Glutathione Glutathione Transferase Liver Function Tests Male Mice Neoplasms, Experimental Chemically Induced Epidemiology Prevention & Control Plant Extracts Superoxide Dismutase Survival Thiobarbituric Acid Reactive Substances Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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