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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Choi, Jae Ho Hwang, Yong Pil Park, Bong Hwan Choi, Chul Yung Chung, Young Chul Jeong, Hye Gwang |
| Description | Author Affiliation: Choi JH ( Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.) |
| Abstract | During the process of liver fibrosis, hepatic stellate cells (HSCs) play a critical role in the increased formation and reduced degradation of extracellular matrix in the liver. We investigated the anti-proliferative effects of an anthocyanin fraction (AF), isolated from the purple-fleshed sweet potato, on platelet-derived growth factor (PDGF)-BB-dependent signaling pathways in HSC-T6 cells. HSC proliferation plays a pivotal role in liver fibrogenesis. The AF suppressed HSC activation, including PDGF-induced proliferation and -smooth muscle actin ( -SMA) expression. Additionally, AF inhibited PDGF-BB-induced Akt and ERK1/2 phosphorylation. AF inhibited the phosphorylation level of PDGF receptor-ß (PDGFR-ß) following PDGF-BB stimulation, providing a mechanism for the inhibition of AF-mediated kinase. These results suggest that AF suppresses HSC proliferation by blocking PDGFR-ß signaling, inhibiting Akt and ERK1/2 activation and -SMA expression. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 31 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Anthocyanins Pharmacology Cell Proliferation Drug Effects Hepatic Stellate Cells Ipomoea Batatas Chemistry Receptors, Platelet-derived Growth Factor Antagonists & Inhibitors Actins Biosynthesis Animals Isolation & Purification Blotting, Western Cell Survival Coloring Agents Extracellular Signal-regulated Map Kinases Physiology L-lactate Dehydrogenase Metabolism Oncogene Protein V-akt Platelet-derived Growth Factor Rats Signal Transduction Tetrazolium Salts Thiazoles Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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