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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jin, Yaping Yu, Fei Liao, Yingjun Liu, Shaoxia Liu, Meimei Xu, Jianhong Yang, Jun |
| Description | Author Affiliation: Jin Y ( Department of Environmental and Occupational Health, School of Public Health, China Medical University, No. 92 Beier Road, Heping District, Shenyang, Liaoning, Postal code: 110001, PR China. jinyp@mail.cmu.edu.cn) |
| Abstract | The aim of this study was to explore therapeutic efficiency of succimer used with calcium and ascorbic acid in the treatment of mildly lead-poisoned mice and preschool children. Mice were exposed to lead by drinking water, and then treated with saline solution, 50mg/kg body weight (b.w.) succimer, 100mg/kg b.w. succimer, or 50mg/kg b.w. succimer plus calcium and ascorbic acid by gavage. Seventy-two children aged 48-72 months were randomly assigned into combined treatment or nutritional intervention group. Lead levels in blood and bone were analyzed by atomic absorption spectrophotometry. Activities of aminolevulinic acid dehydratase (ALAD) in blood were determined by colorimetric method. Results of animal experiment showed that succimer used alone could reduce lead levels in blood and bone and reverse activities of ALAD in blood, however, a better therapeutic efficiency in mobilizing bone lead could be achieved by succimer used with calcium and ascorbic acid. Findings from the clinical study showed that reduction of blood lead levels (BLLs) between the end and initiation of therapy in the combined treatment group was significantly greater than that in the nutritional intervention group. Percentage of children with BLLs less than 10µg/dL at the end of therapy and the eighth week after therapy in the combined treatment group was significantly higher than that in the nutritional intervention group. In conclusion, combined use of succimer with calcium and ascorbic acid seemed to be a choice in the treatment of mildly lead poisoned children. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 31 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Ascorbic Acid Therapeutic Use Calcium Carbonate Pharmacology Chelating Agents Free Radical Scavengers Lead Poisoning Drug Therapy Succimer Aging Metabolism Animals Bone And Bones Chemistry Child Child, Preschool Colorimetry Environmental Exposure Adverse Effects Analysis Female Humans Lead Blood Male Mice Porphobilinogen Synthase Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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