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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Alimi, Hichem Hfaiedh, Najla Bouoni, Zouhour Sakly, Mohsen Ben Rhouma, Khémais |
| Description | Country affiliation: Tunisia Author Affiliation: Alimi H ( Unité de Biochimie Macromoléculaire et Génétique, Faculté des Sciences de Gafsa, Cité Zarroug, 2112 Gafsa, Tunisia. alimihichem@yahoo.fr) |
| Abstract | The Opuntia ficus indica f. inermis methanolic flowers extract (OMFE) was phytochemical studied, in vitro tested for their potential antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power, linoleic acid peroxidation assays and in vivo evaluated for its ability to prevent ethanol-induced gastric ulcer in rats. The OMFE was rich in polysaccharide, phenolics and flavonoids contents and exhibited a moderate in vitro antioxidant activity when compared with (+)-catechin and ascorbic acid. Pre-treatment with OMFE at oral doses 250, 500 and 1000 mg/kg body weight was found to provide a dose-dependent protection against ethanol-induced gastric ulcer by averting the deep necrotic lesions of the gastric epithelium, by preserving normal antioxidant enzymes activities, by inhibiting the lipid peroxidation, the oxidation of protein and the DNA fragmentation in gastric mucosa. The antiulcerogenic activity of OMFE might be due to a possible synergistic antioxidant and antihistaminic-like effects. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 32 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Anti-ulcer Agents Pharmacology Antioxidants Opuntia Chemistry Animals Dna Fragmentation Drug Effects Dose-response Relationship, Drug Drug Evaluation, Preclinical Enzymes Metabolism Ethanol Adverse Effects Flavonoids Flowers Free Radical Scavengers Intestinal Mucosa Linoleic Acid Lipid Peroxidation Male Phenols Plant Extracts Rats Rats, Wistar Stomach Ulcer Chemically Induced Drug Therapy Pathology Toxicity Tests, Acute Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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