NDLI: Identification of a novel P450 gene belonging to the CYP4 family in the clam Ruditapes philippinarum, and analysis of basal- and benzo(a)pyrene-induced mRNA expression levels in selected tissues.

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Identification of a novel P450 gene belonging to the CYP4 family in the clam Ruditapes philippinarum, and analysis of basal- and benzo(a)pyrene-induced mRNA expression levels in selected tissues.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pan, Luqing Liu, Na Xu, Chaoqun Miao, Jingjing
Description	Country affiliation: China Author Affiliation: Pan L ( The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, China. panlq@ouc.edu.cn)
Abstract	A novel full-length cDNA encoding a CYP4 protein was initially cloned from the clam, Ruditapes philippinarum. The nucleotide sequence contained an open reading frame coding for 442 amino acids and the deduced amino acid sequence showed 42.6-49.1% identity with other species CYP4s. The phylogenetic analysis demonstrated that the clam CYP4 was clustered within the CYP4s branch. The clam CYP4 mRNA expression was detected in gill, digestive gland, adductor muscle and mantle, and highest transcription level was observed in digestive gland compared to other tissues. Quantitative real-time RT-PCR analysis revealed that there was no notable change in CYP4 mRNA expression in gill of R. philippinarum exposure to benzo(a)pyrene (BaP), while the mRNA expression was induced significantly in the digestive gland of the clam by 0.2 ppb (µgL(-1)) BaP (p<0.05). The results suggest that CYP4 of the clam may serve as a useful biomarker of marine environmental PAH pollution.
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	32
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2011-11-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Benzo(a)pyrene Toxicity Bivalvia Drug Effects Genetics Cytochrome P-450 Enzyme System Water Pollutants, Chemical Amino Acid Sequence Animals Base Sequence Cloning, Molecular Dna, Complementary Digestive System Gene Expression Regulation Genetic Markers Gills Physiology Molecular Sequence Data Open Reading Frames Phylogeny Polycyclic Hydrocarbons, Aromatic Rna, Messenger Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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Differential gene expression analysis of benzo(a)pyrene toxicity in the clam, Ruditapes philippinarum.

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Identification of a novel P450 gene belonging to the CYP4 family in the clam Ruditapes philippinarum, and analysis of basal- and benzo(a)pyrene-induced mRNA expression levels in selected tissues.

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