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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Priya, T. T. Sabu, M. C. Jolly, C. I. |
| Description | Country affiliation: India Author Affiliation: Priya TT ( Amala Cancer Research Centre, Thrissur, Kerala, India.) |
| Abstract | This study was carried out in order to investigate the potential and antioxidant effects of polyphenols from Mangifera indica stem bark against gastric damage induced by ethanol and cold-restraint stress. The polyphenols possess good capacity for scavenging nitric oxide (NO) radical and ferric-reducing antioxidant power (FRAP) assay in vitro. Rats were sacrificed after the experiment, and their stomachs were removed for biochemical and histopathological analysis. The severity of lesions was found to markedly decrease by the administration of polyphenols in both models. The increased gastric nitrite level of ethanol administered rats were significantly (p < 0.001) reduced by polyphenol treatment. Administration of polyphenols reduced thiobarbituric acid reactive substance (TBARS) level and increased the GSH level significantly in a dose-dependent manner in both models. Our study revealed the ulcer-protective effects of the polyphenols and could possibly reside for the most part on its anti-radical effects. |
| File Format | HTM / HTML |
| ISSN | 14786419 |
| Issue Number | 8 |
| Volume Number | 25 |
| e-ISSN | 14786427 |
| Journal | Natural Product Research |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2011-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Natural products Rats, Wistar Mangifera Toxicity Stress, Physiological Discipline Natural Products Gastric Mucosa Stomach Ulcer Journal Article Etiology Polyphenols Stomach Diseases Restraint, Physical Physiology Glutathione Anti-ulcer Agents Cold Temperature Adverse Effects Ethanol Prevention & Control Rats Pharmacology Plant Bark Metabolism Drug Effects Chemically Induced Pathology Flavonoids Chemistry Animals Thiobarbituric Acid Reactive Substances Ranitidine Phenols |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Plant Science Analytical Chemistry Biochemistry |
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