NDLI: Flavonoids and sesquiterpenes from Tecurium ramosissimum promote antiproliferation of human cancer cells and enhance antioxidant activity: a structure-activity relationship study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ben Sghaier, Mohamed Skandrani, Ines Nasr, Nouha Franca, Marie-Genviève Dijoux Chekir-Ghedira, Leila Ghedira, Kamel
Spatial Coverage	Tunisia
Description	Country affiliation: Tunisia Author Affiliation: Ben Sghaier M ( Unité de Pharmacognosie/Biologie Moléculaire 99/UR/07-03, Faculté de Pharmacie, Rue Avicenne, 5000 Monastir, Tunisia.)
Abstract	Fractionation of the chloroformic extracts from Teucrium ramosissimum leaves resulted in the isolation of three flavonoids: genkwanin (1), cirsimaritin (2) and 4',7-dimethoxy apigenin (4) and one sesquiterpene: ß-eudesmol (3). The structures were determined using data obtained from (1)H and (13)C NMR spectra, as well as by various correlation experiments (COSY, HMQC and HMBC). The antioxidant activities of the isolated flavonoids from T. ramosissimum leaves were evaluated by measuring their ability to scavenge the radical ABTS(+) and through chemical assays: cupric reducing antioxidant capacity (CUPRAC), reducing power (RP) and ferric reducing antioxidant power (FRAP). Furthermore, the effects of T. ramosissimum isolated molecules, on inhibition of cell proliferation and induction of apoptosis in human leukemia cells, were also examined. Cirsimaritin showed the best activity in the ABTS assay with TEAC value 2.04µM, whereas apigenin and 4',7-dimethoxy apigenin exhibited the highest antioxidant activity using the CUPRAC, RP and FRAP assays with TEAC values 10.5, 1.39 and 0.71µM respectively. The cytotoxic activity revealed that the ß-eudesmol inhibited significantly the proliferation of K562 cells (IC(50)=20µg/ml).
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	32
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2011-11-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Antineoplastic Agents, Phytogenic Pharmacology Flavonoids Chemistry Sesquiterpenes Teucrium Antioxidants Apoptosis Drug Effects Cell Line, Tumor Cell Proliferation Drug Screening Assays, Antitumor Flavones Humans K562 Cells Leukemia Drug Therapy Pathology Magnetic Resonance Spectroscopy Molecular Structure Plant Leaves Plants, Medicinal Structure-activity Relationship Tunisia Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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