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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Saoudi, Mongi Ben Hsouna, Anis Trigui, Mohamed Jamoussi, Kamel Jaoua, Samir El Feki, Abdelfattah |
| Description | Country affiliation: Tunisia Author Affiliation: Saoudi M ( Department of Life Sciences, Animal Ecophysiology Laboratory, Sfax, Tunisia. mongifss@yahoo.fr) |
| Abstract | Methanol is primarily metabolized by oxidation to formaldehyde and then to formate. These processes are accompanied by formation of superoxide anion and hydrogen peroxide. This article reports data on the effect of methanol-induced oxidative damage in experimental rats and the role of aqueous extract of Opuntia vulgaris fruit extract (OE) to counteract the toxicity induced by methanol. The animals were exposed to methanol at a dose of 2.37 g/kg body weight intraperitoneally for 30 days. OE was found to contain large amounts of polyphenols and carotenoids and significant antioxidant capacities highlighted by scavenging activities for 2,2-diphenyl-l-picrylhydrazyl. The treatment with methanol exhibited a significant increase in serum hepatic and renal biochemical parameters (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, bilirubin, urea, and creatinine). Methanol intoxication significantly increased hepatic and renal lipid peroxidation evaluated by thiobarbituric acid reactive substances in treated rats as compared to controls. However, hepatic and renal antioxidant enzymes namely superoxide dismutase, catalase, and glutathione peroxidase were significantly decreased in methanol-treated animals as compared to controls. The results concluded that treatment with OE prior to methanol intoxication has significant role in protecting animals from methanol-induced hepatic and renal histopathological and oxidative damage. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 6 |
| Volume Number | 28 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2012-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Free Radical Scavengers Pharmacology Methanol Toxicity Opuntia Chemistry Oxidative Stress Drug Effects Plant Extracts Analysis Of Variance Animals Biological Markers Metabolism Drug-induced Liver Injury Pathology Flavonoids Analysis Fruit Histocytochemistry Injections, Intraperitoneal Kidney Lipid Peroxidation Liver Male Administration & Dosage Phenols Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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