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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Yan Fang, Junyi Huang, Shaoxin Chen, Li Fan, Guangqin Wang, Chunhong |
| Description | Author Affiliation: Wang Y ( Department of Toxicology, School of Public Health, Wuhan University, DongHu Road 115, Wuhan 430071, PR China.) |
| Abstract | Lead is linked to many reproductive problems. This study was to explore the chronic effects of low lead level on expressions of Nrf2 and Mrp1 in rats' testes. Maternal SD rats were administered lead acetate from 10 days before gestation to weaning at three doses respectively after randomization. From each group, 15 male offsprings were then chosen and administrated lead acetate from weaning to six months old at the doses of 0, 0.3 and 0.9g/L respectively. The dose administrations were through drinking water freely. The methods of RT-PCR, Western blotting and immunohistochemistry were used for Mrp1 and Nrf2 of the testes. Compared with control group, significant increases were observed in the expressions of Mrp1 and Nrf2 in two lead groups (P<0.05); nucleus translocation of Nrf2 was observed; both GST and GSH was decreased with increasing the lead dose. In conclusion, Mrp1 might play important roles in lead detoxification by Nrf2. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 35 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Environmental Pollutants Toxicity Lead Multidrug Resistance-associated Proteins Biosynthesis Nf-e2-related Factor 2 Testis Drug Effects Animals Blood Pharmacokinetics Female Glutathione Metabolism Glutathione Disulfide Glutathione Transferase Male Maternal-fetal Exchange Genetics Pregnancy Rna, Messenger Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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