NDLI: Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells.

Please wait, while we are loading the content...

Adenosine deaminase activity and immunoglobulin levels as potential systemic biomonitors of occupational hazards and health status in municipal solid waste management workers.

Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae.

Ginsenoside Rg1 reduces toxicity of PM(2.5) on human umbilical vein endothelial cells by upregulating intracellular antioxidative state.

The relationship of plasma aluminum to oxidant-antioxidant and inflammation status in asthma patients.

Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells.

Alterations in activity and mRNA expression of acetylcholinesterase in the liver, kidney and gill of common carp exposed to atrazine and chlorpyrifos.

Assessment of propofol, midazolam and ziprasidone, or the combinations for the prevention of acute cocaine toxicity in a mouse model.

Toxicity of ZnO nanoparticles in healthy adult mice.

Assessment of the cytotoxic and anti-viral potential of aqueous extracts from different parts of Acacia nilotica (Linn) Delile against Peste des petits ruminants virus.

Acute toxicity of cypermethrin to the non target organism Hyalella curvispina.

impact of aluminum exposure on the immune system: a mini review.

Effects of high-speed railway noise on the synaptic ultrastructure and phosphorylated-CaMKII expression in the central nervous system of SD rats.

Therapeutic effect of coenzyme Q10 against experimentally-induced hepatocellular carcinoma in rats.

The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats.

Salvianic acid A protects L-02 cells against Î³-irradiation-induced apoptosis via the scavenging of reactive oxygen species.

Environmental Risk Assessment of antimicrobials applied in veterinary medicine-A field study and laboratory approach.

Year: 2012 Volume: 34

Year: 2012 Volume: 33

Year: 2011 Volume: 32

Year: 2011 Volume: 31

Year: 2010 Volume: 30

Year: 2010 Volume: 29

Year: 2009 Volume: 28

Year: 2009 Volume: 27

Year: 2008 Volume: 26

Year: 2008 Volume: 25

Year: 2007 Volume: 24

Year: 2007 Volume: 23

Year: 2006 Volume: 22

Year: 2006 Volume: 21

Year: 2005 Volume: 20

Year: 2005 Volume: 19

Year: 2004 Volume: 18

Year: 2004 Volume: 17

Year: 2004 Volume: 16

Year: 2004 Volume: 15

Year: 2003 Volume: 15

Year: 2003 Volume: 14

Year: 2003 Volume: 13

Year: 1996 Volume: 2

Year: 1996 Volume: 1

Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kim, Kil-Nam Ahn, Ginnae Heo, Soo-Jin Kang, Sung-Myung Kang, Min-Cheol Yang, Hye-Mi Kim, Daekyung Roh, Seong Woon Kim, Se-Kwon Jeon, Byong-Tae Park, Pyo-Jam Jung, Won-Kyo Jeon, You-Jin
Description	Author Affiliation: Kim KN ( Marine Bio Research Team, Korea Basic Science Institute (KBSI), Jeju 690-140, Republic of Korea.)
Abstract	The present study was designed to evaluate the molecular mechanisms of fucoxanthin against melanoma cell lines (B16F10 cells). Fucoxanthin reduced the proliferation of B16F10 cells in a dose-dependent manner accompanied by the induction of cell cycle arrest during the G(0)/G(1) phase and apoptosis. Fucoxanthin-induced G(0)/G(1) arrest was associated with a marked decrease in the protein expressions of phosphorylated-Rb (retinoblastoma protein), cyclin D (1 and 2) and cyclin-dependent kinase (CDK) 4 and up-regulation of the protein levels of p15(INK4B) and p27(Kip1). Fucoxanthin-induced apoptosis was accompanied with the down-regulation of the protein levels of Bcl-xL, an inhibitor of apoptosis proteins (IAPs), resulting in a sequential activation of caspase-9, caspase-3, and PARP. Furthermore, the anti-tumor effect of fucoxanthin was assessed in vivo in Balb/c mice. Intraperitoneal administration of fucoxanthin significantly inhibited the growth of tumor mass in B16F10 cells implanted mice.
File Format	HTM / HTML
ISSN	13826689
Issue Number	1
Volume Number	35
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2013-01-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Antineoplastic Agents Therapeutic Use Melanoma, Experimental Drug Therapy Xanthophylls Animals Pharmacology Apoptosis Drug Effects Cell Cycle Cell Cycle Proteins Metabolism Cell Line, Tumor Cell Proliferation Pathology Mice Mice, Inbred Balb C Tumor Burden Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma.

Ligustrazine induces apoptosis of breast cancer cells in vitro and in vivo.

Synthetic phosphoethanolamine a precursor of membrane phospholipids reduce tumor growth in mice bearing melanoma B16-F10 and in vitro induce apoptosis and arrest in G2/M phase.

Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex.

Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo.

Antitumor activity of polysaccharide extracted from Pleurotus ostreatus mycelia against gastric cancer in vitro and in vivo.

Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (−)-gossypol

Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo.

Tetramethylpyrazine inhibits osteosarcoma cell proliferation via downregulation of NF-κB in vitro and in vivo.

Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells.

Similar Documents

In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma.

Ligustrazine induces apoptosis of breast cancer cells in vitro and in vivo.

Synthetic phosphoethanolamine a precursor of membrane phospholipids reduce tumor growth in mice bearing melanoma B16-F10 and in vitro induce apoptosis and arrest in G2/M phase.

Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex.

Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo.

Antitumor activity of polysaccharide extracted from Pleurotus ostreatus mycelia against gastric cancer in vitro and in vivo.

Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (−)-gossypol

Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo.

Tetramethylpyrazine inhibits osteosarcoma cell proliferation via downregulation of NF-κB in vitro and in vivo.

Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells.