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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Li, Mingyong Qiu, Lin Zhang, Yuanyuan Hua, Yi Tu, Shengfen He, Yun Wen, Sheng Wang, Qiang Wei, Guanghui |
| Description | Country affiliation: China Author Affiliation: Li M ( Department of Pediatric Urology Surgery, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing 400014, China.) |
| Abstract | The aim of this study was to evaluate dose-related effects on external genitalia of adult male offspring rats by maternal exposure to di-(2-ethylhexyl) phthalate (DEHP) plasticizer. Timed-pregnant rats were given DEHP by gastric intubation at doses of 0, 500, 750 or 1000mg/kg body weight/day from gestation day 12-19 to establish a hypospadiac rat model. The hypospadias was observed and the incidence in three DEHP dosage levels was 10.7%, 30.6% and 37.0%, respectively. With exposed dose increased, mild, moderate and severe hypospadiac rats were distinguished and an increased incidence of severe hypospadias was observed. The other reproductive lesions like reduced penile length and anogenital distance/body weight were observed. The results indicated the dose-related external genitalia teratogenic toxicity, and graded hypospadias on male offspring was resulted from high dosage DEHP maternal exposure. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 35 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Diethylhexyl Phthalate Toxicity Hypospadias Chemically Induced Plasticizers Prenatal Exposure Delayed Effects Animals Dose-response Relationship, Drug Female Pathology Male Maternal-fetal Exchange Pregnancy Rats Rats, Sprague-dawley Teratogens Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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