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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Di, Guoqing Zheng, Yue |
| Description | Country affiliation: China Author Affiliation: Di G ( Institute of Environmental Pollution & Control Technology, Nongshenghuan Building B388, Zijingang Campus, Zhejiang University, Yuhangtang Road 866, Hangzhou, Zhejiang Province, China. dgq@zju.edu.cn) |
| Abstract | To investigate the toxic effects of high-speed railway noise on learning and memory function, Sprague-Dawley (SD) rats were exposed to high-speed railway noise for 90 days. The noise was recorded from an actual environment and adjusted to a day-night equivalent continuous A-weighted sound pressure level (L(dn)) of 70dB(A). Transmission electron microscopy (TEM) and Western blot analysis were used to observe the synaptic ultrastructure and detect the level of phosphorylated-Ca(2+)/calmodulin-dependent protein kinase II (p-CaMKII), respectively, in the hippocampus, temporal lobe and amygdala. Compared with the sham control group, the results of the TEM showed that the width of the noise model group's synaptic cleft increased markedly in the hippocampus, amygdala (P<0.05) and temporal lobe (P<0.01); the thickness of postsynaptic density (PSD) decreased significantly (P<0.01). The results of the TEM suggest that the synaptic plasticity of structure and function were abnormal and that this abnormality resulted in a reduction in synaptic transmission efficiency. This reduction may have led to dysfunctions in learning and memory. Additionally, the Western blot analyses revealed that the level of p-CaMKII decreased significantly in the temporal lobe of the noise model group compared with the sham control group (P<0.05). The results of the Western blot analysis indicate a reduction in synaptic transmission efficiency, which resulted in impairments in learning and memory function in the temporal lobe. Both of the above conclusions are consistent with each other. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 35 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Brain Ultrastructure Calcium-calmodulin-dependent Protein Kinase Type 2 Metabolism Learning Physiology Memory Noise, Transportation Adverse Effects Railroads Animals Enzymology Male Microscopy, Electron, Transmission Phosphorylation Drug Effects Rats Rats, Sprague-dawley Synapses Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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