NDLI: Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress.

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Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress.

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Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pourgholamhossein, Fatemeh Sharififar, Fariba Rasooli, Rokhsana Pourgholi, Leyla Nakhaeipour, Fatemeh Samareh-Fekri, Hojjat Iranpour, Maryam Mandegary, Ali
Description	Author Affiliation: Pourgholamhossein F ( Pharmaceutics Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Haft-Bagh Blvd., Kerman 7616911319, Iran); Sharififar F ( Department of Pharmacognosy Herbal and Traditional Medicines Research Center, School of Pharmacy, Haft-Bagh Blvd., Kerman 7616911319, Iran. Electronic address: sharififar@yahoo.com.); Rasooli R ( Pharmaceutics Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Haft-Bagh Blvd., Kerman 7616911319, Iran); Pourgholi L ( Department of Toxicology & Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Haft-Bagh Blvd., Kerman 7616911319 , Iran. Electronic address: leyla.pourgholi5@gmail.com.); Nakhaeipour F ( Department of Toxicology & Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Haft-Bagh Blvd., Kerman 7616911319 , Iran. Electronic address: 89bahar73@gmail.com.); Samareh-Fekri H ( Central Research Laboratory, Deputy of Research, Kerman University of Medical Sciences, Haft-Bagh Blvd., Kerman 7616911319, Iran. Electronic address: hojjatfekri@gmail.com.); Iranpour M ( Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman 7617939555, Iran. Electronic address: dr.iranpour.86@gmail.com.); Mandegary A ( Department of Toxicology & Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Haft-Bagh Blvd., Kerman 7616911319 , Iran)
Abstract	The potential preventive and therapeutic effects of thymoquinone (TQ) and its molecular mechanism were evaluated in paraquat (PQ)-induced pulmonary fibrosis in mice. TQ was administered orally at the doses of 20 and 40mg/kg during the course and after development of fibrosis. Pathological changes, expressions of genes involved in fibrogenesis, hydroxyproline (HP) and oxidative stress parameters were determined in the lung tissues. TQ dose-dependently recovered the pathological changes induced by PQ. TQ decreased hydroxyproline content, lipid peroxidation and restored the antioxidant enzymes to the normal values. In molecular level, expressions of TGF-ß1, -SMA, collagen 1a1 and collagen 4a1 genes were also returned to the control level by TQ. This study indicated that TQ has the preventive and therapeutic potentials for the treatment of lung fibrosis by inhibition of oxidative stress and down-regulation of profibrotic genes.
File Format	HTM / HTML
ISSN	13826689
Journal	Environmental Toxicology and Pharmacology
Volume Number	45
e-ISSN	18727077
Language	English
Publisher	Elsevier
Publisher Date	2016-07-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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