| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Zhang, Weixin Yin, Lianhong Tao, Xufeng Xu, Lina Zheng, Lingli Han, Xu Xu, Youwei Wang, Changyuan Peng, Jinyong |
| Description |
Country affiliation: China Author Affiliation: Zhang W ( College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian 116044, China.); Yin L ( College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian 116044, China.); Tao X ( College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian 116044, China.); Xu L ( College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian 116044, China.); Zheng L ( Department of Pharmaceuticals, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. Electronic address: zheng_ll2009@126.com.); Han X ( College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian 116044, China.); Xu Y ( College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian 116044, China.); Wang C ( College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian 116044, China.); Peng J ( College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian 116044, China. Electronic address: jinyongpeng2008@126.com.) |
| Abstract |
In our previous study, the effects of dioscin against alcohol-, carbon tetrachloride- and acetaminophen-induced liver damage have been found. However, the activity of it against dimethylnitrosamine (DMN)-induced acute liver injury remained unknown. In the present study, dioscin markedly decreased serum ALT and AST levels, significantly increased the levels of SOD, GSH-Px, GSH, and decreased the levels of MDA, iNOS and NO. Mechanism study showed that dioscin significantly decreased the expression levels of IL-1ß, IL-6, TNF- , IκB , p50 and p65 through regulating TLR4/MyD88 pathway to rehabilitate inflammation. In addition, dioscin markedly up-regulated the expression levels of SIRT1, HO-1, NQO1, GST and GCLM through increasing nuclear translocation of Nrf2 against oxidative stress. Furthermore, dioscin significantly decreased the expression levels of FasL, Fas, p53, Bak, Caspase-3/9, and upregulated Bcl-2 level through decreasing IRF9 level against apoptosis. In conclusion, dioscin showed protective effect against DMN-induced acute liver injury via ameliorating apoptosis, oxidative stress and inflammation, which should be developed as a new candidate for the treatment of acute liver injury in the future. |
| File Format |
HTM / HTML |
| ISSN |
13826689 |
| Journal |
Environmental Toxicology and Pharmacology |
| Volume Number |
45 |
| e-ISSN |
18727077 |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2016-07-01 |
| Publisher Place |
Netherlands |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Environmental Health Discipline Pharmacology |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
