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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Khalighi, Zahra Rahmani, Asghar Cheraghi, Javad Ahmadi, Mohammad Reza Hafezi Soleimannejad, Koroush Asadollahi, Ruhangiz Asadollahi, Khairollah |
| Description | Country affiliation: Iran Author Affiliation: Khalighi Z ( Department of Internal Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.); Rahmani A ( Student Researches Committee, Ilam University of Medical Sciences, Ilam, Iran.); Cheraghi J ( Department of Physiology, Faculty of Veterinary, Ilam University, Ilam, Iran.); Ahmadi MR ( Department of Pathology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.); Soleimannejad K ( Department of Cardiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.); Asadollahi R ( Department of Pathology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.); Asadollahi K ( Department of Epidemiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Electronic address: Masoud_1241@yahoo.co.uk.) |
| Abstract | The effects of perfluorocarbon (PFC) on paraquat (PQ) induced acute lung injury (ALI) was evaluated among rats. Twenty four Wistar rats were divided into 4 groups: control group injected by saline physiologic 0.9%, PFC group injected by Perfluorocarbon, PQ group injected by PQ and PQ+PFC group injected by PFC one hour after receiving paraquat. Bronchoalveular fluid content, inflammatory cytokines, oxidative and histopathologic changes were measured after 72 h. The levels of interleukin-6 (IL-6), tumor necrosis factor- (TNF- ) and transforming growth factor-ß1(TGF-ß1) in the PQ group were increased compared to either control or PFC groups, but their levels decreased in PQ+PFC group significantly (p<0.05). Also, histopathologic evaluation revealed an increase in malondialdehyde (MDA) and hydroxyproline (HP) in the PQ group but a decrease in PQ+PFC group significantly (p<0.01). PFC emulsion by its anti-inflammatory, anti-oxidative and anti-fibrotic properties can reduce the inflammatory and fibrotic alterations, pulmonary oedema, and pulmonary histopathologic changes created by PQ. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Journal | Environmental Toxicology and Pharmacology |
| Volume Number | 42 |
| e-ISSN | 18727077 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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