NDLI: Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide.

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Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide.

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Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fouad, Amr A. Qutub, Hatem O. Al-Melhim, Walid N.
Description	Author Affiliation: Fouad AA ( Department of Biomedical Sciences, Pharmacology Division, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia. Electronic address: amrfouad65@yahoo.com.); Qutub HO ( Department of Internal Medicine, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.); Al-Melhim WN ( Department of Biomedical Sciences, Histopathology Division, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.)
Abstract	This study investigated the possible hepatoprotection of punicalagin in rats received cyclophosphamide (20mg/kg/day, i.p., for 7 days). Punicalagin given at two doses, 15 and 30mg/kg/day, p.o., for 7 days, starting the same day of cyclophosphamide administration. Punicalagin significantly and dose-dependently reduced the elevations of serum alanine aminotransferase, and liver nuclear factor-κB p65, tumor necrosis factor- , interleukin-1ß, malondialdehyde, nitric oxide, Bax/Bcl-2 ratio, inducible nitric oxide synthase, caspases 3 and 9 activities, and prevented the decrease of hepatic total antioxidant capacity. Punicalagin also attenuated the histopathological liver tissue damage, and decreased cyclooxygenase-2 expression in liver of rats received cyclophosphamide in a dose-dependent manner. It was concluded that punicalagin protected rat liver against cyclophosphamide toxicity by inhibiting oxidative/nitrosative stress, inflammation, and apoptosis.
File Format	HTM / HTML
ISSN	13826689
Journal	Environmental Toxicology and Pharmacology
Volume Number	45
e-ISSN	18727077
Language	English
Publisher	Elsevier
Publisher Date	2016-07-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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