NDLI: Glutathione, glutathione-related enzymes, and oxidative stress in individuals with subacute occupational exposure to lead.

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Glutathione, glutathione-related enzymes, and oxidative stress in individuals with subacute occupational exposure to lead.

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Glutathione, glutathione-related enzymes, and oxidative stress in individuals with subacute occupational exposure to lead.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dobrakowski, Michal Pawlas, Natalia Hudziec, Edyta Kozlowska, Agnieszka Mikolajczyk, Agnieszka Birkner, Ewa Kasperczyk, Slawomir
Description	Author Affiliation: Dobrakowski M ( Department of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze, Poland. Electronic address: michal.dobrakowski@poczta.fm.); Pawlas N ( Institute of Occupational Medicine and Environmental Health in Sosnowiec, ul. Koscielna 13, 41-200 Sosnowiec, Poland.); Hudziec E ( Department of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze, Poland.); Kozlowska A ( Institute of Occupational Medicine and Environmental Health in Sosnowiec, ul. Koscielna 13, 41-200 Sosnowiec, Poland.); Mikolajczyk A ( Institute of Occupational Medicine and Environmental Health in Sosnowiec, ul. Koscielna 13, 41-200 Sosnowiec, Poland.); Birkner E ( Department of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze, Poland.); Kasperczyk S ( Department of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze, Poland.)
Abstract	The aim of the study was to investigate the influence of subacute exposure to lead on the glutathione-related antioxidant defense and oxidative stress parameters in 36 males occupationally exposed to lead for 40±3.2days. Blood lead level in the examined population increased significantly by 359% due to lead exposure. Simultaneously, erythrocyte glutathione level decreased by 16%, whereas the activity of glutathione-6-phosphate dehydrogenase in erythrocytes and leukocytes decreased by 28% and 10%, respectively. Similarly, the activity of glutathione-S-transferase in erythrocytes decreased by 45%. However, the activity of glutathione reductase in erythrocytes and leukocytes increased by 26% and 6%, respectively, whereas the total oxidant status value in leukocytes increased by 37%. Subacute exposure to lead results in glutathione pool depletion and accumulation of lipid peroxidation products; however, it does not cause DNA damage. Besides, subacute exposure to lead modifies the activity of glutathione-related enzymes.
File Format	HTM / HTML
ISSN	13826689
Journal	Environmental Toxicology and Pharmacology
Volume Number	45
e-ISSN	18727077
Language	English
Publisher	Elsevier
Publisher Date	2016-07-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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