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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Jing Zhang, Yue Zhu, Qiuzhen Liu, Yulan Cheng, Hao Zhang, Yuefan Li, Tiejun |
| Description | Country affiliation: China Author Affiliation: Wang J ( College of Pharmacology, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China); Zhang Y ( College of Pharmacology, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China.); Zhu Q ( Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.); Liu Y ( Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.); Cheng H ( College of Pharmacology, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China.); Zhang Y ( Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China. Electronic address: zhangyuefan@126.com.); Li T ( Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China) |
| Abstract | The aim of this study was to explore the protective effect of emodin, a plant-derived anthraquinone, against gamma radiation-induced mortality and intestinal injury in mice, and to investigate the radioprotective molecular mechanism. C57BL/6 male mice were pre-treated with emodin for 7days via oral gavage before gamma radiation. We found that pretreatment with emodin prolonged mice survival time after 9Gy total body irradiation (TBI). Mice were sacrificed at 1 week after 7Gy TBI, we found that emodin attenuated intestinal morphological changes and increased villus height, crypt numbers, and reduced villus and crypt apoptosis as well as inhibited the expression of p53. MTT assay, flow cytometry, Hoechst 33258 staining, real-time PCR, and Western blotting indicated that emodin pretreatment can effectively increase human umbilical venous endothelial cells (HUVECs) viability and attenuate cell apoptosis; it also inhibited the expression of p53, Bax, and Caspase3 in HUVECs after irradiation. In summary, these results suggest the potential of emodin as an effective radioprotectant against radiation-induced intestinal injury. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Journal | Environmental Toxicology and Pharmacology |
| Volume Number | 46 |
| e-ISSN | 18727077 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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