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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bhatia, A. L. Manda, Kailash |
| Description | Country affiliation: India Author Affiliation: Bhatia AL ( Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302004, India.) |
| Abstract | Antioxidants are part of the primary cellular defense against radiation-generated free radicals. Reports on low-level chronic administration of melatonin with its antiradiation influence are scanty. Although compelling logic suggests that melatonin may be effective for a variety of disorders, the mode and optimal dose of melatonin are still not clear. Most studies have used doses of supraphysiological blood levels. Present investigation reported that pre-treatment with the lower concentration of melatonin (0.1mg/kg b.w./day) for 15 consecutive days affords potential protective effect against radiation-induced oxidative stress and mortality in mice. Radiation-induced augmentation in the levels of lipid peroxidation, glutathione disulphide (GSSG) and acid phosphatase was significantly ameliorated by melatonin pre-treatment. Radiation-induced depletion in the level of reduced glutathione (GSH), as well as glutathione peroxidase (GSH-Px) and alkaline phosphatase activities, was inhibited significantly by melatonin administration. Regression analysis of survival data yielded LD(50/30) as 7.16 and 11Gy for control (irradiation alone) and experimental (melatonin-treated irradiated) mice, respectively, and produced a dose reduction factor (DRF), 1.53. Radiation-induced deficit in the body and organ weight also got inhibited significantly in the melatonin pre-treated mice. The findings support property of melatonin as a free radical scavenger and singlet oxygen quencher and indicate the antioxidative properties of melatonin against the gamma radiation. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Journal | Environmental Toxicology and Pharmacology |
| Volume Number | 18 |
| e-ISSN | 18727077 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2004-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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