NDLI: Peroxisome proliferator-activated receptor gamma (PPARÎ³) in brown trout: Interference of estrogenic and androgenic inputs in primary hepatocytes.

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Peroxisome proliferator-activated receptor gamma (PPARÎ³) in brown trout: Interference of estrogenic and androgenic inputs in primary hepatocytes.

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Peroxisome proliferator-activated receptor gamma (PPARÎ³) in brown trout: Interference of estrogenic and androgenic inputs in primary hepatocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lopes, Célia Madureira, Tânia Vieira Ferreira, Nádia Pinheiro, Ivone Castro, L. Filipe C. Rocha, Eduardo
Description	Author Affiliation: Lopes C ( Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), U.Porto - University of Porto, Rua dos Bragas 289, P 4050-123 Porto, Portugal); Madureira TV ( Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), U.Porto - University of Porto, Rua dos Bragas 289, P 4050-123 Porto, Portugal); Ferreira N ( Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), U.Porto - University of Porto, Rua dos Bragas 289, P 4050-123 Porto, Portugal); Pinheiro I ( Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), U.Porto - University of Porto, Rua dos Bragas 289, P 4050-123 Porto, Portugal); Castro LF ( Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), U.Porto - University of Porto, Rua dos Bragas 289, P 4050-123 Porto, Portugal); Rocha E ( Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), U.Porto - University of Porto, Rua dos Bragas 289, P 4050-123 Porto, Portugal)
Abstract	Peroxisome proliferator-activated receptor gamma (PPARÎ³) is a pivotal regulator of lipid and glucose metabolism in vertebrates. Here, we isolated and characterized for the first time the PPARÎ³ gene from brown trout (Salmo trutta f. fario). Hormones have been reported to interfere with the regulatory function of PPARÎ³ in various organisms, albeit with little focus on fish. Thus, primary hepatocytes isolated from juveniles of brown trout were exposed to 1, 10 and 50µM of ethinylestradiol (EE2) or testosterone (T). A significant (3 fold) decrease was obtained in response to 50µM of EE2 and to 10 and 50µM of T (13 and 14 folds), while a 3 fold increase was observed at 1µM of EE2. Therefore, trout PPARÎ³ seems a target for natural/synthetic compounds with estrogenic or androgenic properties and so, we advocate considering PPARÎ³ as another alert sensor gene when assessing the effects of sex-steroid endocrine disruptors.
File Format	HTM / HTML
ISSN	13826689
Journal	Environmental Toxicology and Pharmacology
Volume Number	46
e-ISSN	18727077
Language	English
Publisher	Elsevier
Publisher Date	2016-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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