NDLI: Glyphosate induces cardiovascular toxicity in Danio rerio.

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Glyphosate induces cardiovascular toxicity in Danio rerio.

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Glyphosate induces cardiovascular toxicity in Danio rerio.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Roy, Nicole M. Ochs, Jeremy Zambrzycka, Ewelina Anderson, Ariann
Description	Author Affiliation: Roy NM ( Department of Biology, Sacred Heart University, Fairfield, CT, United States. Electronic address: royn@sacredheart.edu.); Ochs J ( Department of Biology, Sacred Heart University, Fairfield, CT, United States.); Zambrzycka E ( Department of Biology, Sacred Heart University, Fairfield, CT, United States.); Anderson A ( Department of Biology, Sacred Heart University, Fairfield, CT, United States.)
Abstract	Glyphosate is a broad spectrum herbicide used aggressively in agricultural practices as well as home garden care. Although labeled 'safe' by the chemical industry, doses tested by industry do not mimic chronic exposures to sublethal doses that organisms in the environment are exposed to over long periods of time. Given the widespread uses of and exposure to glyphosate, studies on developmental toxicity are needed. Here we utilize the zebrafish vertebrate model system to study early effects of glyphosate on the developing heart. Treatment by embryo soaking with 50µg/ml glyphosate starting at gastrulation results in structural abnormalities in the atrium and ventricle, irregular heart looping, situs inversus as well as decreased heartbeats by 48h as determined by live imaging and immunohistochemistry. Vasculature in the body was also affected as determined using fli-1 transgenic embryos. To determine if the effects noted at 48h post fertilization are due to early stage alterations in myocardial precursors, we also investigate cardiomyocyte development with a Mef2 antibody and by mef2ca in situ hybridization and find alterations in the Mef2/mef2ca staining patterns during early cardiac patterning stages. We conclude that glyphosate is developmentally toxic to the zebrafish heart.
File Format	HTM / HTML
ISSN	13826689
Journal	Environmental Toxicology and Pharmacology
Volume Number	46
e-ISSN	18727077
Language	English
Publisher	Elsevier
Publisher Date	2016-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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