NDLI: Ligustrazine attenuates inflammation and the associated chemokines and receptors in ovalbumine-induced mouse asthma model.

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Ligustrazine attenuates inflammation and the associated chemokines and receptors in ovalbumine-induced mouse asthma model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wei, Ying Liu, Jiaqi Zhang, Hongying Du, Xin Luo, Qingli Sun, Jing Liu, Feng Li, Mihui Xu, Fei Wei, Kai Dong, Jingcheng
Description	Country affiliation: China Author Affiliation: Wei Y ( Department of Integrative Medicine, Huashan Hospital, Fudan University, China); Liu J ( Department of Integrative Medicine, Huashan Hospital, Fudan University, China); Zhang H ( Department of Integrative Medicine, Huashan Hospital, Fudan University, China); Du X ( Department of Integrative Medicine, Huashan Hospital, Fudan University, China); Luo Q ( Department of Integrative Medicine, Huashan Hospital, Fudan University, China); Sun J ( Department of Integrative Medicine, Huashan Hospital, Fudan University, China); Liu F ( Department of Integrative Medicine, Huashan Hospital, Fudan University, China); Li M ( Department of Integrative Medicine, Huashan Hospital, Fudan University, China); Xu F ( Department of Integrative Medicine, Huashan Hospital, Fudan University, China); Wei K ( Department of Integrative Medicine, Huashan Hospital, Fudan University, China); Dong J ( Department of Integrative Medicine, Huashan Hospital, Fudan University, China)
Abstract	Ligustrazine which is isolated from Chinese herb ligusticum chuanxiong hort, has been widely used in traditional Chinese medicine (TCM) for asthma treatment. In this study, we aim to observe the effect of ligustrazine on inflammation and the associated chemokines and receptors in ovalbumin (OVA)-induced mouse asthma model. Our data demonstrates that ligustrazine suppresses airway hyperresponsiveness to methacholine and lung inflammation in OVA-induced mouse asthma model. Ligustrazine also induces inhibition of inflammatory cells including neutrophils, lymphocytes and eosinophils. In addition, ligustrazine significantly reduces IL-4, IL-5, IL-17A, CCL3, CCL19 and CCL21 level in BALF of asthma mice. Furthermore, ligustrazine induces down-regulation of CCL19 receptor CCR7, STAT3 and p38 MAPK protein expression. Collectively, these results suggest that ligustrazine is effective in attenuation of allergic airway inflammatory changes and related chemokines and receptors in OVA-induced asthma model, and this action might be associated with inhibition of STAT3 and p38 MAPK pathway, which indicates that ligustrazine may be used as a potential therapeutic method to treat asthma.
File Format	HTM / HTML
ISSN	13826689
Journal	Environmental Toxicology and Pharmacology
Volume Number	46
e-ISSN	18727077
Language	English
Publisher	Elsevier
Publisher Date	2016-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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