NDLI: Curcumin protects against cypermethrin-induced genotoxicity in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sankar, Palanisamy Telang, A. G. Manimaran, Ayyasamy
Description	Country affiliation: India Author Affiliation: Sankar P ( Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, 243122 Bareilly, Uttar Pradesh, India.)
Abstract	Cypermethrin is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control, protection of foodstuff and disease vector control. The aim of the present study was to investigate the protective effect of curcumin on cypermethrin-induced genotoxicity in rats. Administration of cypermethrin (25mg/kg, p.o.) for 28 days resulted in significant increase in the frequency of micronuclei formation in bone marrow cells and DNA damage in blood cells. Curcumin (100mg/kg, p.o.) administration caused significant reduction in micronuclei formation and, marked reduction in DNA damage. The present study revealed that presence of curcumin could diminish cypermethrin-induced genotoxicity in rats.
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Journal	Environmental Toxicology and Pharmacology
Volume Number	30
e-ISSN	18727077
Language	English
Publisher	Elsevier
Publisher Date	2010-11-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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Curcumin protects against cypermethrin-induced genotoxicity in rats.