NDLI: Clearance of Aspergillus fumigatus is impaired in the airway in allergic inflammation.

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Clearance of Aspergillus fumigatus is impaired in the airway in allergic inflammation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fukahori, Susumu Matsuse, Hiroto Tsuchida, Tomoko Kawano, Tetsuya Nishino, Tomoya Fukushima, Chizu Kohno, Shigeru
Description	Country affiliation: Japan Author Affiliation: Fukahori S ( Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.); Matsuse H ( Division of Respirology, Toho University Ohashi Medical Center, Tokyo, Japan. Electronic address: hiroto.matsuse@med.toho-u.ac.jp.); Tsuchida T ( Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.); Kawano T ( Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.); Nishino T ( Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.); Fukushima C ( Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.); Kohno S ( Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.)
Abstract	BACKGROUND: Aspergillus fumigatus (Af) sometimes colonizes and persists within the respiratory tree in some patients with asthma. To date, the precise reasons why the clearance of Af is impaired in patients with asthma remain unknown. OBJECTIVE: To characterize the effects of allergic airway inflammation on clearance of Af. METHODS: Control and Dermatophagoides farinae (Df) allergen-sensitized BALB/c mice were intranasally infected with Af. After 2 and 9 days of infection, the pathology, fungal burden, and cytokine profile in lung tissue were compared. In a different set of experiments, the phagocytotic activity of alveolar macrophages and the expression of their pathogen recognition receptors also were determined. RESULTS: The Af conidia and neutrophilic airway inflammation disappeared by day 9 after infection in control mice. In Df-sensitized mice, Af conidia and neutrophilic and eosinophilic airway inflammation persisted at day 9 after infection. Compared with control mice, Df allergen-sensitized mice showed significant increases in interleukin (IL)-5 and decreases in IL-12 and interferon-Î³ in lung tissues at day 2 after infection. Most importantly, compared with Af-infected non-Df-sensitized mice, IL-17 in lung tissues was significantly decreased in Df allergen-sensitized Af-infected mice at day 2 after infection but was significantly increased at day 9. Alveolar macrophages isolated from Df allergen-sensitized mice exhibited significant decreases in phagocytotic activity and expression of Toll-like receptor-4 and dectin-1 compared with those from control mice. CONCLUSION: In the airway of patients with allergy, T-helper cell type 2-dominant immunity potentially affects the expression of pathogen recognition receptors and attenuates cellular defense against Af. Prolonged IL-17 production also could play an important role.
File Format	HTM / HTML
ISSN	10811206
Issue Number	2
Volume Number	113
e-ISSN	15344436
Journal	Annals of Allergy, Asthma & Immunology
Language	English
Publisher	Elsevier (on behalf of the American College of Allergy, Asthma and Immunology)
Publisher Date	2014-08-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Aspergillosis Immunology Aspergillus Fumigatus Bronchial Hyperreactivity Th17 Cells Th2 Cells Animals Antigens, Dermatophagoides Pathology Pathogenicity Asthma Microbiology Cystic Fibrosis Dermatophagoides Farinae Humans Interferon-gamma Interleukin-12 Interleukin-17 Interleukin-5 Lung Macrophages, Alveolar Mice Mice, Inbred Balb C Neutrophil Activation Phagocytosis Pneumonia Pulmonary Eosinophilia Respiratory System Th1 Cells Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Immunology and Allergy Immunology

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