NDLI: Chemokine expression in diverse nonimmediate drug hypersensitivity reactions: focus on thymus activation-regulated chemokine, cutaneous T-cell-attracting chemokine, and interleukin-10.

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Chemokine expression in diverse nonimmediate drug hypersensitivity reactions: focus on thymus activation-regulated chemokine, cutaneous T-cell-attracting chemokine, and interleukin-10.

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Chemokine expression in diverse nonimmediate drug hypersensitivity reactions: focus on thymus activation-regulated chemokine, cutaneous T-cell-attracting chemokine, and interleukin-10.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Fang He, Dingyang Tang, Xuhua Zhang, Xingqi
Description	Country affiliation: China Author Affiliation: Wang F ( Department of Dermatology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.); He D ( Department of Dermatology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.); Tang X ( Department of Dermatology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.); Zhang X ( Department of Dermatology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China. Electronic address: xingqizhang@hotmail.com.)
Abstract	BACKGROUND: Skin infiltration of different types of T lymphocytes is responsible for inflammatory profiles of nonimmediate drug hypersensitivity reactions (niDHRs). Important chemokines attracting skin-specific homing T cells include thymus activation-regulated chemokine (TARC) and cutaneous T-cell-attracting chemokine (CTACK). Interleukin-10 (IL-10) is a potent chemokine attracting CD8(+) T cells. OBJECTIVE: To investigate serum levels of TARC, CTACK, and IL-10 in patients with niDHRs and evaluate the correlation among these 3 chemokines. METHODS: Forty patients, including 19 patients with Stevens-Johnson syndrome and toxic epidermal necrolysis and 21 patients with maculopapular exanthema, and 21 healthy donors were recruited into the study. Clinical data of patients were obtained. Serum TARC, CTACK, and IL-10 levels were determined by enzyme-linked immunosorbent assay. RESULTS: Serum levels of TARC, CTACK, and IL-10 were significantly elevated in patients with niDHRs compared with those in normal controls (P < .05, P < .001, P < .001, respectively). The CTACK and IL-10 levels were significantly higher (P < .05, P < .001) in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis than in normal controls. Patients with maculopapular exanthema exhibited higher levels of TARC, CTACK, and IL-10 compared with normal controls (P < .001, P < .001, P < .05). Serum CTACK levels were positively correlated with TARC levels in all 40 patients (rs = 0.3422, P < .05). Serum CTACK levels positively correlated with detachment of body surface area in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis (rs = 0.510, P < .05). CONCLUSION: These results support a role for TARC, CTACK, and IL-10 in the pathogenesis of niDHRs for their chemotactic ability to attract different T-cell subtypes and different functional severities in niDHRs.
File Format	HTM / HTML
ISSN	10811206
Issue Number	2
Volume Number	113
e-ISSN	15344436
Journal	Annals of Allergy, Asthma & Immunology
Language	English
Publisher	Elsevier (on behalf of the American College of Allergy, Asthma and Immunology)
Publisher Date	2014-08-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Chemokine Ccl17 Blood Chemokine Ccl27 Drug Hypersensitivity Immunology Interleukin-10 T-lymphocyte Subsets Adolescent Adult Aged Chemotaxis Dermatitis, Atopic Chemically Induced Drug Eruptions Complications Mortality Exanthema Female Humans Male Middle Aged Skin Pathology Stevens-johnson Syndrome Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Immunology and Allergy Immunology

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Chemokine expression in diverse nonimmediate drug hypersensitivity reactions: focus on thymus activation-regulated chemokine, cutaneous T-cell-attracting chemokine, and interleukin-10.

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