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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Matsumoto, Mitsuharu Ebata, Toshiya Hirooka, Junko Hosoya, Ritsuko Inoue, Natsuhiko Itami, Satomi Tsuji, Kazuo Yaginuma, Taketoshi Muramatsu, Koji Nakamura, Atsuo Fujita, Ayako Nagakura, Toshikazu |
| Description | Author Affiliation: Matsumoto M ( Dairy Science and Technology Institute, Kyodo Milk Industry Co Ltd, Hinode, Tokyo, Japan. Electronic address: m-matumoto@meito.co.jp.); Ebata T ( Chitofuna Dermatology Clinic, Setagaya, Tokyo, Japan.); Hirooka J ( Hirooka Clinic, Shinjuku, Tokyo, Japan.); Hosoya R ( Hosoya Dermatology Clinic, Komae, Tokyo, Japan.); Inoue N ( Inoue Clinic, Kawasaki, Kanagawa, Japan.); Itami S ( Itami Skin Clinic, Kashiwa, Chiba, Japan.); Tsuji K ( Tsuji Clinic, Shibuya, Tokyo, Japan.); Yaginuma T ( Yaginuma Dermatology Clinic, Kashiwa, Chiba, Japan.); Muramatsu K ( Dairy Science and Technology Institute, Kyodo Milk Industry Co Ltd, Hinode, Tokyo, Japan.); Nakamura A ( Dairy Science and Technology Institute, Kyodo Milk Industry Co Ltd, Hinode, Tokyo, Japan.); Fujita A ( Dairy Science and Technology Institute, Kyodo Milk Industry Co Ltd, Hinode, Tokyo, Japan.); Nagakura T ( Yoga Allergy Clinic, Setagaya, Tokyo, Japan.) |
| Abstract | BACKGROUND: Evidence suggests that intestinal microbiota play an important role in the pathogenesis of atopic dermatitis (AD) through induction of immunosuppression and immune tolerance; however, the exact underlying mechanism is unclear. Few studies to date have examined the effects of probiotics on adult-type AD. OBJECTIVE: To examine the effects of the probiotic Bifidobacterium animalis subsp lactis LKM512 on adult-type AD and the expression of metabolites that are known to be influenced by gut microbiota in fecal samples. METHODS: Forty-four patients were randomly assigned to receive LKM512 or a placebo and underwent medical examinations. Fecal microbiota were analyzed with real-time polymerase chain reaction. Metabolomic analysis was conducted to search for antipruritic metabolites produced by intestinal bacteria using feces derived from 3 patients whose itch scores had improved using capillary electrophoresis with time-of-flight mass spectrometry. Antipruritic effects of kynurenic acid were observed using AD-induced NC/Nga mice. RESULTS: LKM512 administration alleviated itch in AD patients compared with controls and improved the dermatology-specific quality-of-life scores when compared with the controls. Administration of LKM512 also increased the expression of the antipruritic and antinociceptive metabolite kynurenic acid (KYNA) in patients whose itch score had improved after LKM512 treatment. In mouse experiments, scratching behavior counts tended to be decreased by KYNA injection when compared with no treatment. CONCLUSION: LKM512 administration may exert antipruritic effects by increasing KYNA production. LKM512 could therefore be a potentially effective therapeutic candidate for the reduction of pruritus. TRIAL REGISTRATION: umin.ac.jp/ctr Identifier: UMIN000005695. |
| File Format | HTM / HTML |
| ISSN | 10811206 |
| Issue Number | 2 |
| Volume Number | 113 |
| e-ISSN | 15344436 |
| Journal | Annals of Allergy, Asthma & Immunology |
| Language | English |
| Publisher | Elsevier (on behalf of the American College of Allergy, Asthma and Immunology) |
| Publisher Date | 2014-08-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Antipruritics Therapeutic Use Bifidobacterium Immunology Dermatitis, Atopic Drug Therapy Kynurenic Acid Probiotics Adult Analgesics Pharmacology Animals Feces Microbiology Female Humans Immune Tolerance Immunosuppression Intestines Lactic Acid Analogs & Derivatives Metabolism Male Metabolomics Mice Microbiota Polyamines Pruritus Quality Of Life Journal Article Randomized Controlled Trial |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Immunology and Allergy Immunology |
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