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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Del Prete, Gianfranco Chiumiento, Lorena Amedei, Amedeo Piazza, Maria D'Elios, Mario M. Codolo, Gaia de Bernard, Marina Masetti, Massimo Bruschi, Fabrizio |
| Description | Country affiliation: Italy Author Affiliation: Del Prete G ( Department of Internal Medicine, University of Florence, Florence, Italy. gdelprete@unifi.it) |
| Abstract | BACKGROUND: The Helicobacter pylori neutrophil-activating protein (HP-NAP) is able to induce IL-12 expression by cells of innate immunity and to shift to T(H)1 human allergen-specific T(H)2 cells in vitro. OBJECTIVE: We performed an in vivo investigation of the ability of HP-NAP to downmodulate the T(H)2 response induced in mice by Trichinella spiralis infection. METHODS: Groups of T spiralis-infected BALB/c mice received intraperitoneal PBS/rat IgG2b (control animals) or 10 microg of HP-NAP with or without anti-Toll-like receptor 2 antibody on days 10 and 28 after infection. Blood eosinophils, total and T spiralis-specific IgE levels, and cytokine levels were measured in the plasma up to day 42, when splenocytes were cultured for cytokine production. RESULTS: Although control animals showed significant eosinophilia and increase of total and T spiralis-specific IgE, IL-4, and IL-5 levels from days 10 to 14, HP-NAP-treated animals showed less eosinophilia and total and excretory/secretory antigens of T spiralis-specific IgE in the blood. HP-NAP-treated animals also had higher IL-12 and IFN-gamma plasma levels and lower IL-4 and IL-5 levels. The addition of anti-Toll-like receptor 2 antibody abrogated the anti-T(H)2/pro-T(H)1 activity of HP-NAP. CONCLUSION: This study provides evidence that HP-NAP enhances endogenous IL-12 and IFN-gamma response and exerts a powerful anti-T(H)2 activity in vivo, targeting both IL-5-induced eosinophilia and IL-4-mediated hyper-IgE responses induced by parasitic infection. |
| File Format | HTM / HTML |
| ISSN | 00916749 |
| e-ISSN | 10976825 |
| Journal | Journal of Allergy and Clinical Immunology |
| Issue Number | 5 |
| Volume Number | 122 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Immunology Bacterial Proteins Immunology Th2 Cells Trichinella Spiralis Trichinellosis Animals Antigens, Bacterial Disease Models, Animal Down-regulation Eosinophilia Immunoglobulin E Interferon-gamma Interleukin-12 Interleukin-4 Interleukin-5 Mice Mice, Inbred Balb C Th1 Cells Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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