NDLI: First patient treated with a re-challenge of catumaxomab in recurrent malignant ascites: a case report.

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First patient treated with a re-challenge of catumaxomab in recurrent malignant ascites: a case report.

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First patient treated with a re-challenge of catumaxomab in recurrent malignant ascites: a case report.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pietzner, Klaus Jäger, Michael Schoberth, Alexandra Oskay-Özcelik, Gülten Kuhberg, Marc Lindhofer, Horst Sehouli, Jalid
Description	Country affiliation: Germany Author Affiliation: Pietzner K ( Charité-Campus Virchow Klinikum, Department for Gynecology and Obstetrics, University Medicine of Berlin, European Competence Center for Ovarian Cancer (EKZE), Augustenburger Platz 1, 13353 Berlin, Germany. klaus.pietzner@charite.de)
Abstract	In the past, treatment for malignant ascites focussed on symptomatic relief or treatment of the underlying disease. A promising option evolved with catumaxomab (Removab(®)) in 2009. Since catumaxomab is a bispecific, trifunctional antibody with mouse-rat origin, so far repeated treatment cycles were not an option due to the occurrence of human anti-drug antibodies (HADA). Nevertheless, the good results obtained so far raised the question whether a repeated treatment cycle with catumaxomab could be feasible and effective. We report on a 74-year-old female patient with breast cancer and peritoneal carcinomatosis. To our knowledge, this is the first patient world-wide to be treated with a repeated cycle of catumaxomab. HAMA (human anti-mouse antibodies) values were identified in blood and ascites samples. Ascites samples were also stained to identify and quantify cells, positive for EpCAM (epithelial cell adhesion molecule) and CD45. The patient tolerated the second cycle without unexpected side effects and remained puncture-free for another 45 days. Analysis of blood and ascites revealed a quick increase in HAMA values in the blood samples after 1 week, but considerably lower HAMA values and delayed increase in the ascites samples. Also a distinct and continuous decrease of EpCAM-positive cells was observed in the ascites samples under treatment. A strong increase in CD45-positive cells was detected after the beginning of the second cycle, with a consecutive decline toward the end. This first experience suggests that a repeated cycle of catumaxomab might be feasible and effective. As a consequence, a phase II trial (SECIMAS) was initiated.
File Format	HTM / HTML
ISSN	13570560
Issue Number	2
Volume Number	29
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Secondary Carcinoma, Lobular Complications Humans Drug Therapy Neoplasm Recurrence, Local Treatment Outcome Breast Neoplasms Therapeutic Use Journal Article Case Reports Peritoneal Neoplasms Pathology Etiology Antibodies, Bispecific Female Aged Ascites Neoplasm Staging Discipline Oncology
Content Type	Text
Resource Type	Case study Article
Subject	Hematology Cancer Research Oncology

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