NDLI: Overexpression of Nanog protein is associated with poor prognosis in gastric adenocarcinoma.

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Overexpression of Nanog protein is associated with poor prognosis in gastric adenocarcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lin, Ting Ding, Yan-Qing Li, Jian-Ming
Description	Author Affiliation: Lin T ( Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China.)
Abstract	Nanog, a key transcription factor in self-renewal and pluripotency of embryonic stem cells, has been proved to play a novel role in solid tumor development. Here, we investigated Nanog protein expression in retrospective clinical samples of 105 patients underwent resective surgery for gastric adenocarcinoma. We found that Nanog protein immunostaining in tumor tissues was stronger than that in their corresponding non-dysplastic tissues. However, no statistical difference of Nanog protein expression between tumor tissues and metastatic lymph nodes was found (P = 0.143). Interestingly, overexpression of Nanog protein was correlated with advanced clinical stage of patients with gastric adenocarcinoma (P = 0.006). And Nanog protein expression was correlated with lymph node status (P = 0.004), infiltrating extent (P = 0.001), and differentiation (P = 0.000) of patients with gastric adenocarcinoma. Survival analysis showed that overexpression of Nanog protein in gastric cancer patients predicted a poorer prognosis (P = 0.000). Our data first demonstrated a potential diagnostic and prognostic role of Nanog for gastric adenocarcinoma.
File Format	HTM / HTML
ISSN	13570560
Issue Number	2
Volume Number	29
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Adenocarcinoma Prognosis Comparative Study Carcinoma, Signet Ring Cell Humans Middle Aged Male Immunoenzyme Techniques Journal Article Female Retrospective Studies Stomach Neoplasms Discipline Oncology Stomach Secondary Tumor Markers, Biological Neoplasm Invasiveness Mortality Survival Rate Lymphatic Metastasis Metabolism Pathology Homeodomain Proteins Follow-up Studies Neoplasm Staging
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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