NDLI: The expression and clinical significance of the androgen receptor and E-cadherin in triple-negative breast cancer.

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The expression and clinical significance of the androgen receptor and E-cadherin in triple-negative breast cancer.

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The expression and clinical significance of the androgen receptor and E-cadherin in triple-negative breast cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tang, Dabei Xu, Shanqi Zhang, Qingyuan Zhao, Wenhui
Description	Country affiliation: China Author Affiliation: Tang D ( Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, 150040 Harbin, China.)
Abstract	Triple-negative breast cancer (TNBC) has a poor prognosis and lacks prognostic indicators. The androgen receptor (AR) and E-cadherin are involved in the pathogenesis of breast cancer, but their roles are not clearly defined. We designed this study to evaluate AR and E-cadherin expression and to determine their relationships with the clinicopathologic parameters of triple-negative breast cancer. The present study included 127 TNBC patients. Immunohistochemical stains for AR and E-cadherin were performed, and the relationships between AR and E-cadherin expression and clinicopathologic data and prognosis were analyzed. We found that in TNBC patients, AR was expressed in 16(12.6%) cases, and E-cadherin was expressed in 41(33.0%) cases. AR expression was associated with tumor grade (P = 0.004) and menopausal status (P = 0.017), and E-cadherin expression was associated with node status (P= 0.016). A multivariate analysis demonstrated that tumor size, tumor grade, lymph node status, and E-cadherin were of prognostic significance for disease-free interval and overall survival. Compared with AR-positive patients, AR-negative patients showed significantly poorer outcomes with respect to the disease-free interval (P = 0.047) and overall survival (P = 0.038). E-cadherin-negative patients experienced shorter disease-free interval (P = 0.016) and poorer overall survival (P = 0.012) than did E-cadherin-positive patients. An AR-positive and E-cadherin-negative expression profile was associated with recurrence or metastasis (P = 0.036). Moreover, as the expression of nuclear AR increased (25% vs. 33.3%, P = 0.361), less E-cadherin staining was observed in TNBC samples. This finding suggested that AR and E-cadherin expression could be a useful prognostic marker for classifying subgroups of TNBC.
File Format	HTM / HTML
ISSN	13570560
Issue Number	2
Volume Number	29
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Research Support, Non-u.s. Gov't Prognosis Carcinoma, Lobular Humans Middle Aged Breast Neoplasms Receptors, Androgen Immunoenzyme Techniques Journal Article Neoplasm Grading Adult Female Receptor, Erbb-2 Carcinoma, Ductal, Breast Discipline Oncology Secondary Tumor Markers, Biological Receptors, Estrogen Neoplasm Invasiveness Mortality Neoplasm Recurrence, Local Survival Rate Lymphatic Metastasis Metabolism Pathology Receptors, Progesterone Follow-up Studies Cadherins Aged Neoplasm Staging
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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