NDLI: A Phase II trial of Zoladex combined with CEF chemotherapy as neoadjuvant therapy in premenopausal women with hormone-responsive, operable breast cancer.

Please wait, while we are loading the content...

Year: 2017 Volume: 34

Year: 2016 Volume: 33

Year: 2015 Volume: 32

Year: 2014 Volume: 31

Year: 2013 Volume: 30

Year: 2012 Volume: 29

Year: 2012 Volume: 29 Issue: 5

Year: 2012 Volume: 29 Issue: 4

Year: 2012 Volume: 29 Issue: 3

Year: 2012 Volume: 29 Issue: 2

Imatinib mesylate may induce long-term clinical response in FIP1L1-PDGFR -negative hypereosinophilic syndrome.

Radiation-induced sarcoma of head and neck: 50 years of experience at a single institution in an endemic area of nasopharyngeal carcinoma in China.

Prognostic value of androgen receptor expression in operable triple-negative breast cancer: a retrospective analysis based on a tissue microarray.

Aberrant microRNA expression in human cervical carcinomas.

EGFR expression correlates with decreased disease-free survival in triple-negative breast cancer: a retrospective analysis based on a tissue microarray.

miR-107 targets cyclin-dependent kinase 6 expression, induces cell cycle G1 arrest and inhibits invasion in gastric cancer cells.

Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients.

Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II.

The analysis of CD45 isoforms expression on HBV-specific T cells after liver transplantation.

Smoking reduces survival in young females with lung adenocarcinoma after curative resection.

Sequential treatment with sorafenib and sunitinib in metastatic renal cell carcinoma: clinical outcomes from a retrospective clinical study.

DW-MRI ADC values can predict treatment response in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy.

Accuracy of GFR estimation by the Cockroft and Gault, MDRD, and Wright equations in Oncology patients with renal impairment.

CXCL12 G801A polymorphism is associated with an increased risk of benign salivary gland tumors in the Chinese population.

Correlation between T-cadherin gene expression and aberrant methylation of T-cadherin promoter in human colon carcinoma cells.

Clinicopathologic features and prognosis analysis of mucinous gastric carcinoma.

Health-related quality of life as prognostic factor for response, progression-free survival, and survival in women with metastatic breast cancer.

Familial diabetes is associated with reduced risk of cancer in diabetic patients: a possible role for metformin.

Phase II study of oxaliplatin plus leucovorin and 5-fluorouracil in heavily pretreated metastatic breast cancer patients.

Metformin and cancer: new applications for an old drug.

Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters.

Prognostic significance of kappaB-Ras1 expression in gliomas.

Arsenic trioxide induces apoptosis of p53 null osteosarcoma MG63 cells through the inhibition of catalase.

Type 1 receptor parathyroid hormone (PTH1R) influences breast cancer cell proliferation and apoptosis induced by high levels of glucose.

The influence of intraoperative pleural perfusion with matrine-cisplatin or cisplatin on stromal cell-derived factor-1 in non-small cell lung cancer patients with subclinical pleural metastasis.

Analysis of HER2 gene amplification and protein expression in esophageal squamous cell carcinoma.

The serum bone morphogenetic protein-2 level in non-small-cell lung cancer patients.

Primary malignant melanoma of the penis: a case report.

Pseudolymphoma of the orbit.

Is there an association between human immunodeficiency virus infection and breast cancer?

Primary sarcomatoid malignant mesothelioma of the pericardium.

Comorbidity as a risk factor for overall survival and decision criteria for intensity of chemotherapy in elderly patients with acute myeloid leukemia.

Overexpression of Nanog protein is associated with poor prognosis in gastric adenocarcinoma.

Profile of infections and outcome in high-risk febrile neutropenia: experience from a tertiary care cancer center in India.

Second-line chemotherapy in metastatic docetaxel-resistant prostate cancer: a review.

The overexpression of AP-4 as a prognostic indicator for gastric carcinoma.

Radiation-induced chronic oxidative renal damage can be reduced by amifostine.

Reactivation of Syk gene by AZA suppresses metastasis but not proliferation of breast cancer cells.

Phenytoin- and cranial radiotherapy-induced toxic epidermal necrolysis treated with combination therapy: systemic steroid and intravenous immunoglobulin.

Association between Gly1619ARG polymorphism of IGF2R domain 11 (rs629849) and advanced stage of oral cancer.

MicroRNA-146a is down-regulated in gastric cancer and regulates cell proliferation and apoptosis.

Second-line neoadjuvant vinorelbine and gemcitabine combination in locally advanced breast cancer showing no early response to TAC.

Magnetic resonance imaging is appropriate for determining the osteotomy plane for appendicular osteosarcoma after neoadjuvant chemotherapy.

Her-2 prognostic value in very early-stage breast cancer: a single-institution retrospective analysis.

A case report of a 33-year chronic phase survivor of chronic myeloid leukemia.

Telomere shortening occurs early during gastrocarcinogenesis.

PTEN's regulation of VEGF and VEGFR1 expression and its clinical significance in myeloid leukemia.

The TP53 gene polymorphisms and survival of sporadic breast cancer patients.

Bilateral breast involvement of Hodgkin lymphoma revealed by FDG PET/CT.

HLA class-II allele frequencies in Turkish breast cancer patients.

Identification of a new translocation that disrupts the RUNX1 gene in a patient with de novo acute myeloid leukemia.

Clinical review and analysis of complications of totally implantable venous access devices for chemotherapy.

Targeted therapy with trastuzumab for advanced salivary ductal carcinoma: case report and literature review.

A Phase II trial of Zoladex combined with CEF chemotherapy as neoadjuvant therapy in premenopausal women with hormone-responsive, operable breast cancer.

The correlation between IGF-II and Bcl-2 expression in colorectal adenocarcinoma.

Accuracy of positron emission tomography in mediastinal node assessment in coal workers with lung cancer.

Second-line chemotherapy with docetaxel and carboplatin in paclitaxel and platinum-pretreated ovarian, fallopian tube, and peritoneal cancer.

Brain metastasis from ovarian cancer: case report and review of the literature.

Fibroblasts and extracellular matrix differently modulate MMP activation by primary and metastatic head and neck cancer cells.

Multidisciplinary treatment with chemotherapy, targeted drug, and high-intensity focused ultrasound in advanced pancreatic carcinoma.

Clinical characteristics and prognostic factors in Chinese patients with Hodgkin's lymphoma.

Reversible posterior leukoencephalopathy induced by carboplatin and etoposide.

Interstitial pneumonitis induced by pegylated liposomal doxorubicin in a patient with recurrent ovarian cancer.

Surgical outcomes of gastrointestinal stromal tumors of the stomach: a single unit experience in the era of targeted drug therapy.

Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer.

Clinical correlation of MGMT protein expression and promoter methylation in Chinese glioblastoma patients.

Cowden syndrome: a major indication for extensive cancer surveillance.

The biological characteristics of adult CD34+ acute promyelocytic leukemia.

Phase II trial of gefitinib in pretreated Chinese women with advanced non-small-cell lung cancer.

ER-/ER+ breast cancer cell lines exhibited different resistance to paclitaxel through pulse selection.

Meta-analysis of concomitant compared to sequential adjuvant trastuzumab in breast cancer: the sooner the better.

Expression of Toll-like receptor 4 and beta 1 integrin in breast cancer.

Caveolin-1 is related to invasion, survival, and poor prognosis in hepatocellular cancer.

Prognostic value of hedgehog signaling pathway in patients with colon cancer.

Durable remission of leptomeningeal metastases from hormone-responsive prostate cancer.

The correlation between tumor-infiltrating Foxp3+ regulatory T cells and cyclooxygenase-2 expression and their association with recurrence in resected head and neck cancers.

Prognostic stratification of patients with T3N1M0 non-small cell lung cancer: which phase should it be?

Zoledronic acid inhibits proliferation and impairs migration and invasion through downregulating VEGF and MMPs expression in human nasopharyngeal carcinoma cells.

Clinical features and pedigree report of a patient with giant neurofibroma.

Cytoplasmic sequestration of wild-type p53 in a patient with therapy-related resistant AML: first report.

Amyloid-like fibrils are not detected in non-small cell lung cancer tissue samples.

Systemic alterations in concentrations and distribution of plasma phospholipids in prostate cancer patients.

PTP1B expression contributes to gastric cancer progression.

Successful treatment of chronic hiccup with baclofen in cancer patients.

Translocation t(X;10)(p10;p10): a rare chromosomal abnormality in a new born female with acute myeloid leukemia.

The expression and significance of pThr32-FOXO3a in human ovarian cancer.

MAGE-3 and MAGE-4 genes as possible markers for early detection of metastases in hepatitis C virus Egyptian patients complicated by hepatocellular carcinoma.

Apoptosis in esophagus and pancreas carcinoma cells induced by circulating microparticles is related to phosphatidyl serine and microparticle-associated caspases.

Antitumor activity of total paeony glycoside against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo.

Concurrent and sequential administration of sunitinib malate and docetaxel in human non-small cell lung cancer cells and xenografts.

Refractory generalized seizures as a possible side effect of bevacizumab in a colon cancer patient.

The major stressful life events and cancer: stress history and cancer.

Posttreatment plasma VEGF levels may be associated with the overall survival of patients with advanced non-small cell lung cancer treated with bevacizumab plus chemotherapy.

Molecular cytogenetic study of derivative chromosome 9 deletion in chronic myeloid leukemia patients.

O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation.

Patient counseling program to improve the compliance to imatinib in chronic myeloid leukemia patients.

Does Kaposi's sarcoma predict multicentric Castleman disease in the presence of generalized lymphadenopathy?

Unusual presentation of gastric plasmablastic lymphoma in HIV-negative patient.

Association of follicular lymphoma risk with BRCA2 N372H polymorphism in Slovak population.

Bortezomib-based chemotherapy for light chain deposition disease presenting as acute renal failure.

The expression of SOX11, cyclin D1, cyclin D2, and cyclin D3 in B-cell lymphocytic proliferative diseases.

Killer cell immunoglobulin-like receptor genes in patients with breast cancer.

Safety and treatment patterns of angiogenesis inhibitors in patients with metastatic renal cell carcinoma: evidence from US community oncology clinics.

Prognostic significance of APE1 cytoplasmic localization in human epithelial ovarian cancer.

Inhibiting ERp29 expression enhances radiosensitivity in human nasopharyngeal carcinoma cell lines.

Prostate-specific antigen: its relationship with alcohol intake and tobacco.

Polymorphic CA repeat length in insulin-like growth factor 1 and risk of breast cancer in Iranian women.

Aldehyde dehydrogenase-1 is a specific marker for stem cells in human lung adenocarcinoma.

MiR-221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2.

Phase II study of pemetrexed plus oxaliplatin for platinum-resistant advanced or metastatic non-small cell lung cancer patients.

Small cell carcinoma of the urinary bladder with hypercalcemia.

Absence of human papillomavirus in patients with breast cancer in north-west China.

Nanoparticles targeting HLA-G for gene therapy in cancer.

Cementoplasty for painful bone metastases: a series of 42 cases.

Pericardial effusion and tamponade following interferon alpha treatment for locally advanced melanoma.

IGHV gene rearrangements as outcome predictors for CLL patients: experience of Ukrainian group.

5-Fluorouracil or capecitabine in the treatment of advanced colorectal cancer: a pooled-analysis of randomized trials.

Colonic metastasis from primary lung adenocarcinoma: case report and review of the literature.

DAPK promoter hypermethylation in tissues and body fluids of oral precancer patients.

Eleven years of experience with AIDS-related lymphomas at the Institute of Oncology Ljubljana.

High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer.

Potential role of AQP1 and VEGF in the development of malignant pleural effusion in mice.

Down-regulation of lysyl oxidase-like 2 (LOXL2) is associated with disease progression in lung adenocarcinomas.

The expression and clinical significance of the androgen receptor and E-cadherin in triple-negative breast cancer.

Assessment of the involvement of oxidative stress and Mitogen-Activated Protein Kinase signaling pathways in the cytotoxic effects of arsenic trioxide and its combination with sulindac or its metabolites: sulindac sulfide and sulindac sulfone on human leukemic cell lines

Classical CMF regimen as adjuvant chemotherapy for triple-negative breast cancer may be more effective compared with anthracycline or taxane-based regimens.

Co-existence of t(6;13)(p21;q14.1) and trisomy 12 in chronic lymphocytic leukemia.

Study on predictive role of AR and EGFR family genes with response to neoadjuvant chemotherapy in locally advanced breast cancer in Indian women.

Successful treatment of recurrent malignancy-associated hemophagocytic lymphohistiocytosis with a modified HLH-94 immunochemotherapy and allogeneic stem cell transplantation.

Effect of short hairpin RNA of Bcl-xL gene on biological behaviors of HepG-2 cells.

Plasma VEGF levels may not accurately reflect the truth all the time.

Implications of transcriptional factor, OCT-4, in human bladder malignancy and tumor recurrence.

First patient treated with a re-challenge of catumaxomab in recurrent malignant ascites: a case report.

Characterization of arsenic-induced cytogenetic alterations in acute promyelocytic leukemia cell line, NB4

Prognostic value of oncoprotein expressions in thyroid papillary carcinoma.

Prognostic significance of galectin-3 and cyclin D1 expression in undifferentiated nasopharyngeal carcinoma.

A retrospective statistical analysis of high-grade soft tissue sarcomas.

Carbohydrate antigen 242 highly consists with carbohydrate antigen 19-9 in diagnosis and prognosis of colorectal cancer: study on 185 cases.

The effect of prophylactic lamivudine on hepatitis B virus reactivation in HBsAg-positive patients with diffuse large B-cell lymphoma undergoing prolonged rituximab therapy.

Expression of GPC3 protein and its significance in lung squamous cell carcinoma.

Clinical significance of vascular endothelial growth factor and endostatin levels in the differential diagnosis of malignant and benign ascites.

The biological behavior of SDF-1/CXCR4 in patients with myelodysplastic syndrome.

Temsirolimus in renal cell carcinoma with sarcomatoid differentiation: a report of three cases.

MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility.

Tetramethylpyrazine reverses multidrug resistance in breast cancer cells through regulating the expression and function of P-glycoprotein.

Effect of rs6983267 polymorphism in the 8q24 region and rs4444903 polymorphism in EGF gene on the risk of sporadic colorectal cancer in Iranian population.

Outcome of non-metastatic male breast cancer: 118 patients.

Differentiated prostatic antigen expression in LNCaP cells following treatment with bispecific antisense oligonucleotides directed against BCL-2 and EGFR.

Meat intake and risk of bladder cancer: a meta-analysis.

Pioglitazone, etoricoxib, interferon- , and metronomic capecitabine for metastatic renal cell carcinoma: final results of a prospective phase II trial.

Prognostic value of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and aminopeptidase N/CD13 in breast cancer patients.

UHRF1 is associated with tumor recurrence in non-muscle-invasive bladder cancer.

Acute transient encephalopathy after weekly paclitaxel infusion.

Fourth ventricular choroid plexus papilloma.

A potential role for the homeoprotein Hhex in hepatocellular carcinoma progression.

Clinical implications of mismatched repair gene promoter methylation in pancreatic cancer.

Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer.

Loss of CD20 antigen expression after rituximab therapy of CD20 positive B cell lymphoma (diffuse large B cell extranodal marginal zone lymphoma combination): a case report and review of the literature.

Year: 2012 Volume: 29 Issue: 1

Year: 2011 Volume: 28

Year: 2010 Volume: 27

Year: 2009 Volume: 26

Year: 2008 Volume: 25

A Phase II trial of Zoladex combined with CEF chemotherapy as neoadjuvant therapy in premenopausal women with hormone-responsive, operable breast cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Sheng Zhang, Chongjian Liu, Jingjing Qin, Li Cui, Shude Zhang, Jin
Description	Author Affiliation: Zhang S ( 3rd Department of Breast Cancer, Tianjin Medical University Cancer Hospital, West Beihuanhu Rd., 300060 Tianjin, People's Republic of China.)
Abstract	The purpose of this study was to evaluate the efficacy and safety of Zoladex combined with CEF chemotherapy as neoadjuvant therapy in hormone-responsive, premenopausal, operable breast cancer. One hundred and nineteen patients with hormone-responsive, premenopausal, operable breast cancer were enrolled in the study. Zoladex at 3.6 mg was given by subcutaneous injection every 4 weeks for 3 cycles. CEF (cyclophosphamide, 600 mg/m(2), epirubicin, 60-90 mg/m(2), and fluorouracil 500 mg/m(2)) was administered every 3 weeks for 4 cycles as neoadjuvant therapy. The primary objective was a pathologic complete response (PCR) rate in the breast. Thirty-one patients (26.1%) achieved a clinical complete response, and 76 patients (63.9%) achieved a clinical partial response; the clinical response rate was 90.0%. Fourteen patients (11.8%) achieved a pathologic complete response (T0/Tis, N0), and 20 patients (16.8%) achieved a pathologic complete response (T0/Tis, Nx). When stratified by the clinical lymph node status, the clinical partial response rate in the clinical lymph node negative group was significantly higher than in the clinical lymph node positive group (P = 0.02). When stratified by hormonal status, the clinical partial response rate in the ER and PR + group was significantly better than the ER or PR- group (P = 0.0471). There were no treatment-related deaths and no grades 3 or 4 toxicity. The most common adverse event was nausea (grade 1 65.5%, grade 2 18.5%), vomiting (grade 1 58.8%, grade 2 13.4%), and alopecia (grade 1 45.4%, grade 2 54.6%). Zoladex combined with CEF chemotherapy was effective as neoadjuvant therapy in hormone-responsive, premenopausal breast cancer. This regimen was particularly effective in the clinical lymph node negative group and in the ER/PR double positive group. (ClinicalTrials.gov number, NCT00488722).
File Format	HTM / HTML
ISSN	13570560
Issue Number	2
Volume Number	29
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Prognosis Humans Middle Aged Breast Neoplasms Journal Article Neoplasm Grading Surgery Neoadjuvant Therapy Adult Female Epirubicin Receptor, Erbb-2 Discipline Oncology Fluorouracil Clinical Trial, Phase Ii Premenopause Receptors, Estrogen Drug Therapy Antineoplastic Combined Chemotherapy Protocols Administration & Dosage Metabolism Lymph Nodes Therapeutic Use Pathology Cyclophosphamide Receptors, Progesterone Follow-up Studies Neoplasm Staging Goserelin
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in