NDLI: Phenytoin- and cranial radiotherapy-induced toxic epidermal necrolysis treated with combination therapy: systemic steroid and intravenous immunoglobulin.

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Phenytoin- and cranial radiotherapy-induced toxic epidermal necrolysis treated with combination therapy: systemic steroid and intravenous immunoglobulin.

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Phenytoin- and cranial radiotherapy-induced toxic epidermal necrolysis treated with combination therapy: systemic steroid and intravenous immunoglobulin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fidan, E. Fidan, M. Ozdemir, F. Kavgaci, H. Aydin, F.
Description	Country affiliation: Turkey Author Affiliation: Fidan E ( Department of Medical Oncology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey. evrenfidan@yahoo.com)
Abstract	Toxic epidermal necrolysis (TEN) is a rare dermatological disease that causes serious morbidity and mortality. It may be caused by antibiotics, anticonvulsants, nonsteroidal anti-inflammatory agents, allopurinol, infections, autoimmune diseases, and radiotherapy. A 49-year-old man was admitted to our hospital because of skin changes. Prophylactic phenytoin was administered, and cranial radiotherapy was planned for brain metastases. During these treatments, erythematous lesions and blisters were observed on his scalp, face, neck, the front and back of his body, and his arms. Detachment of the skin, especially on the back, was also observed. TEN was diagnosed, and phenytoin was discontinued. Methylprednisolone 80 mg/day IV and intravenous immunoglobulin 1 g/kg/day were applied for treatment. After 10 days, skin recovery and re-epithelialization were established, temperature decreased, and mucosal hemorrhage ceased. The patient was discharged after 2 weeks.
File Format	HTM / HTML
ISSN	13570560
Issue Number	2
Volume Number	29
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Adenocarcinoma Therapy Prognosis Humans Middle Aged Free Radical Scavengers Male Methylprednisolone Journal Article Brain Neoplasms Case Reports Etiology Anti-inflammatory Agents Drug Therapy, Combination Discipline Oncology Secondary Adverse Effects Complications Drug Therapy Combined Modality Therapy Stevens-johnson Syndrome Cranial Irradiation Therapeutic Use Pentoxifylline Pathology Anticonvulsants Rectal Neoplasms Immunoglobulins, Intravenous Phenytoin
Content Type	Text
Resource Type	Case study Article
Subject	Hematology Cancer Research Oncology

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