NDLI: Toward accelerated bone regeneration by altering poly(D,L-lactic-co-glycolic) acid porogen content in calcium phosphate cement.

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Toward accelerated bone regeneration by altering poly(D,L-lactic-co-glycolic) acid porogen content in calcium phosphate cement.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Van Houdt, C. I. A. Preethanath, R. S. Van Oirschot, B. A. J. A. Zwarts, P. H. W. Ulrich, D. J. O. Anil, S. Jansen, J. A. Van Den Beucken, J. J. J. P.
Description	Country affiliation: Netherlands Author Affiliation: van Houdt CI ( Department of Biomaterials, Radboudumc university medical center, Nijmegen, The Netherlands.); Preethanath RS ( Department of Biomaterials, Radboudumc university medical center, Nijmegen, The Netherlands.); van Oirschot BA ( Department of Periodontics and Community Dentistry, King Saud University, Riyadh, Saudi Arabia.); Zwarts PH ( Department of Biomaterials, Radboudumc university medical center, Nijmegen, The Netherlands.); Ulrich DJ ( Department of Biomaterials, Radboudumc university medical center, Nijmegen, The Netherlands.); Anil S ( Department of Plastic and Reconstructive Surgery, Radboudumc, Nijmegen, The Netherlands.); Jansen JA ( Department of Periodontics and Community Dentistry, King Saud University, Riyadh, Saudi Arabia.); van den Beucken JJ ( Department of Biomaterials, Radboudumc university medical center, Nijmegen, The Netherlands.)
Abstract	This work aimed to compare in vitro degradation of dense PLGA microspheres and milled PLGA particles as porogens within CPC, considering that the manufacturing of milled PLGA is more cost-effective when compared with PLGA microspheres. Additionally, we aimed to examine the effect of porogen amount within CPC/PLGA on degradation and bone formation. Our in vitro results showed no differences between both forms of PLGA particles (as porogens in CPC; spherical for microspheres, irregular for milled) regarding morphology, porosity, and degradation. Using milled PLGA as porogens within CPC/PLGA, we evaluated the effect of porogen amount on degradation and bone forming capacity in vivo. Titanium landmarks surrounded by CPC/PLGA with 30 and 50 wt % PLGA, were implanted in forty femoral bone defects of twenty male Wistar rats. Histomorphometrical results showed a significant temporal decrease in the amount of CPC, for both formulas, and confirmed that 50 wt % PLGA degrades faster than 30 wt%, and allows for a 1.5-fold higher amount of newly formed bone. Taken together, this study demonstrated that (i) milled PLGA particles perform equal to PLGA microspheres, and (ii) tuning of the PLGA content in CPC/PLGA is a feasible approach to leverage material degradation and bone formation.
File Format	HTM / HTML
ISSN	15493296
Issue Number	2
Volume Number	104
e-ISSN	15524965
Journal	Journal of Biomedical Materials Research Part A
Language	English
Publisher	Wiley
Publisher Date	2016-02-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Femur Bone Cements Rats, Wistar Lactic Acid Polyglycolic Acid Rats Male Bone Regeneration Pharmacology Metabolism Drug Effects Journal Article Discipline Biomedical Engineering Calcium Phosphates Pathology Chemistry Animals Porosity Injuries Osteogenesis
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering

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